Thymidine, 4',5'-didehydro-5'-deoxy-

Base Information

Chemical Name:Thymidine, 4',5'-didehydro-5'-deoxy-
CAS No.:28034-72-2
Molecular Formula:C10H12N2O4
Molecular Weight:224.216
Hs Code.:
Mol file:28034-72-2.mol

Synonyms:1-(2,5-dideoxy-β-D-glycero-pent-4-enofuranosyl)thymine;4',5'-didehydro-5'-deoxy-thymidine;5'-deoxythymidin-4'-ene;

Suppliers and Price of Thymidine, 4',5'-didehydro-5'-deoxy-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of Thymidine, 4',5'-didehydro-5'-deoxy-

Chemical Property:

PSA：84.32000
LogP:-0.36150

Purity/Quality:: 99.3% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Thymidine, 4',5'-didehydro-5'-deoxy-

There total 2 articles about Thymidine, 4',5'-didehydro-5'-deoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 25953-14-4,94892-66-7
1-((2R,4S,5S)-4-hydroxy-5-(iodomethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

: 13307-75-0
(phenylthio)methyllithium

: 133076-55-8
1-[(2R,4S,5R)-4-Hydroxy-5-(2-phenylsulfanyl-ethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 28034-72-2
1-((2R,4S)-4-hydroxy-5-methylenetetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran;

Reference yield:

: 25953-14-4,94892-66-7
1-((2R,4S,5S)-4-hydroxy-5-(iodomethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

: 93-91-4
1-phenylbutan-1,3-dione

: 133076-50-3
1-[(2R,4S,5R)-5-(3,5-Dioxo-5-phenyl-pentyl)-4-hydroxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 28034-72-2
1-((2R,4S)-4-hydroxy-5-methylenetetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -78 deg C, 2.) RT, 4 h;

Reference yield:

: 24630-67-9
hydroxymethyl-phosphonic acid dimethyl ester

: 28034-72-2
1-((2R,4S)-4-hydroxy-5-methylenetetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

: dimethyl (1-thymin-1-yl-1,2,5-trideoxy-α-L-threo-pentofuranos-4-yloxy)methylphosphonate

: dimethyl (1-thymin-1-yl-1,2,5-trideoxy-β-D-erythro-pentofuranos-4-yloxy)methylphosphonate

Guidance literature:: With 4 A molecular sieve; pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃; for 36h;
DOI:10.1016/j.tet.2007.03.059