Technology Process of 8-fluoro-2-phenylchroman-4-one
There total 2 articles about 8-fluoro-2-phenylchroman-4-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
pentacarbonyl{1-(1-methoxy-3(E)-phenyl-2-propenylidene)}chromium(0); 2-fluoro-6-iodophenol;
With
triphenyl phosphite; palladium diacetate; potassium carbonate; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate;
In
water; 1,2-dichloro-ethane;
at 40 ℃;
for 8h;
Inert atmosphere;
Schlenk technique;
With
toluene-4-sulfonic acid;
In
water; 1,2-dichloro-ethane;
at 50 ℃;
for 0.5h;
Inert atmosphere;
Schlenk technique;
DOI:10.1002/anie.201707590
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine; chloro-trimethyl-silane / diethyl ether / 20 °C / Inert atmosphere
2.1: triphenyl phosphite; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; palladium diacetate; potassium carbonate / 1,2-dichloro-ethane; water / 8 h / 40 °C / Inert atmosphere; Schlenk technique
2.2: 0.5 h / 50 °C / Inert atmosphere; Schlenk technique
With
triphenyl phosphite; chloro-trimethyl-silane; palladium diacetate; potassium carbonate; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; triethylamine;
In
diethyl ether; water; 1,2-dichloro-ethane;
2.1: |Tsuji-Trost Allylation;
DOI:10.1002/anie.201707590
