28177-50-6

Basic information

• Product Name: 2-FLUORO-6-IODOPHENOL,98%
• Synonyms: 2-FLUORO-6-IODOPHENOL,98%
• CAS NO: 28177-50-6
• Molecular Formula: C₆H₄FIO
• Molecular Weight: 238
• Product Categories: Phenol&Thiophenol&Mercaptan
• Mol File: 28177-50-6.mol

Chemical Properties

• Boiling Point: 169.319 °C at 760 mmHg
• Flash Point: 56.203 °C
• Appearance: /
• Density: 2.085g/cm³
• Vapor Pressure: 1.17mmHg at 25°C
• Refractive Index: 1.638
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-FLUORO-6-IODOPHENOL,98%(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-6-IODOPHENOL,98%(28177-50-6)
• EPA Substance Registry System: 2-FLUORO-6-IODOPHENOL,98%(28177-50-6)

Safety Data

• Hazardous Substances Data: 28177-50-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-6-iodophenol, 98% is used as a building block for the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be incorporated into the development of new drugs and medications.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Fluoro-6-iodophenol, 98% is used as a starting material for the synthesis of agrochemicals. Its properties make it suitable for the development of pesticides, herbicides, and other agricultural chemicals.
Used in Dye Industry:
2-Fluoro-6-iodophenol, 98% is used in the synthesis of dyes due to its chemical properties. It serves as a key intermediate in the production of various types of dyes used in different industries.
Used as a Reagent in Organic Synthesis:
2-Fluoro-6-iodophenol, 98% is used as a reagent in organic synthesis. Its unique structure allows it to participate in various chemical reactions, making it a valuable tool in the synthesis of complex organic compounds.
Used in Research and Development:
Due to its high purity, 2-Fluoro-6-iodophenol, 98% is often used in research and development applications. It is particularly useful in experiments where precise and accurate results are required, such as in the development of new chemical processes or the study of chemical reactions.

InChI:InChI=1/C6H4FIO/c7-4-2-1-3-5(8)6(4)9/h1-3,9H

Upstream product

• 899427-21-5 2-fluoro-6-iodophenyl isopropylcarbamate 
• 870777-22-3 2-fluoro-6-iodophenylboronic acid 
• 367-12-4 2-fluorophenol 
• 199585-08-5 2-fluorophenyl isopropylcarbamate 

Downstream Products

• 1148-21-6 8-fluoro-2-phenylchroman-4-one 
• 1075184-34-7 2-fluoro-6-iodophenyl trifluoromethanesulfonate 
• 363-52-0 3-fluorocatechol 
• 861928-17-8 2-fluoro-3,6-diiodoanisole 
• 32750-21-3 1-fluoro-3-iodo-2-methoxybenzene 

Relevant articles and documents

PROCESS FOR PRODUCING 1,2-DIALKOXY-3-FLUOROBENZENE

The present invention relates to a process for producing a 2-fluoro-6-halophenol as an intermediate; a process for producing a 2-alkoxy-3-fluorophenol and further a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; a second process for producing a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; and a 2-alkoxy-3-fluorophenol. The 2-fluoro-6-halophenol can be obtained using a 2-fluorophenol as a starting material and through a sulfonation reaction, a halogenation reaction, and a deprotection reaction. The 2-fluoro-6-halophenol is alkyl-etherified, and subsequently the halogen atom is converted into a hydroxyl group to obtain the 2-alkoxy-3-fluorophenol, which is further alkyl-etherified to thereby obtain the 1,2-dialkoxy-3-fluorobenzene. Alternatively, a 1,2-dialkoxy-3-fluorobenzene is also obtained by converting the halogen atom of the 2-fluoro-6-halophenol into a hydroxyl group to thereby form 3-fluorocatechol and subsequently alkyl-etherifying two hydroxyl groups thereof. The processes of the invention realize low production costs and high process yields, and thus are suitable for industrial production of a 1,2-dialkoxy-3-fluorobenzene.

Synthesis of halogenated phenols by directed ortho-lithiation and ipso-iododesilylation reactions of O-aryl N-isopropylcarbamates

The regioselective synthesis of halogenated phenols via directed ortho-lithiation reactions of in situ N-silylated O-aryl N-isopropylcarbamates is reported. This protocol is complemented by ipso-iododesilylation reactions of C-silylated carbamates and iodine-magnesium exchange reactions, which are facilitated by the adjacent carbamoyl group. These methods provide an entry into a series of o-fluoro-, o-iodo-, and o,o′-diiodophenols in high yields which are otherwise difficult to obtain. Georg Thieme Verlag Stuttgart.

Halogen-lithium exchange between substituted dihalobenzenes and butyllithium: Application to the regioselective synthesis of functionalized bromobenzaldehydes

Halogen-lithium interconversion reactions between unsymmetrically substituted mono- and bifunctional dihalobenzenes C6H 3XHal2 and C6H2XYHal2 (Hal=Br, I; X, Y=F, OR, CF3, CH(OMe)2) and butyllithium were investigated. The resultant organolithium intermediates were converted into the corresponding benzaldehydes in moderate to good yields. As a rule, bromine atoms in the position ortho to the functional group were replaced preferentially with lithium. Intramolecular competition experiments with bifunctional systems revealed that fluorine is capable of activating the neighboring bromine atom more strongly than methoxy and dimethoxymethyl groups. On the replacement of the non-activated bromine with iodine a complete reversal of this reactivity pattern can be accomplished due to the preferred iodine-lithium exchange.