28177-50-6

Basic information

• Product Name: 2-FLUORO-6-IODOPHENOL,98%
• Synonyms: 2-FLUORO-6-IODOPHENOL,98%
• CAS NO: 28177-50-6
• Molecular Formula: C₆H₄FIO
• Molecular Weight: 238
• Product Categories: Phenol&Thiophenol&Mercaptan
• Mol File: 28177-50-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 169.319 °C at 760 mmHg
• Flash Point: 56.203 °C
• Appearance: /
• Density: 2.085g/cm³
• Vapor Pressure: 1.17mmHg at 25°C
• Refractive Index: 1.638
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-FLUORO-6-IODOPHENOL,98%(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-6-IODOPHENOL,98%(28177-50-6)
• EPA Substance Registry System: 2-FLUORO-6-IODOPHENOL,98%(28177-50-6)

Safety Data

• Hazardous Substances Data: 28177-50-6(Hazardous Substances Data)

Usage

General Description

2-Fluoro-6-iodophenol is a chemical compound that is 98% pure and is commonly used in the pharmaceutical and chemical industries. It is a white to light yellow crystalline substance that is known for its strong odor. 2-Fluoro-6-iodophenol is used in the synthesis of various pharmaceuticals, agrochemicals, and dyes. It is also used as a reagent in organic synthesis and as a building block for more complex chemical compounds. This chemical is known for its high purity and is often used in research and development applications where precise and accurate results are required.

InChI:InChI=1/C6H4FIO/c7-4-2-1-3-5(8)6(4)9/h1-3,9H

Upstream product

• 870777-22-3 2-fluoro-6-iodophenylboronic acid 
• 367-12-4 2-fluorophenol 
• 199585-08-5 2-fluorophenyl isopropylcarbamate 
• 899427-21-5 2-fluoro-6-iodophenyl isopropylcarbamate 

Downstream Products

• 861928-17-8 2-fluoro-3,6-diiodoanisole 
• 1148-21-6 8-fluoro-2-phenylchroman-4-one 
• 1075184-34-7 2-fluoro-6-iodophenyl trifluoromethanesulfonate 
• 363-52-0 3-fluorocatechol 
• 32750-21-3 1-fluoro-3-iodo-2-methoxybenzene 

Relevant articles and documents

PROCESS FOR PRODUCING 1,2-DIALKOXY-3-FLUOROBENZENE

The present invention relates to a process for producing a 2-fluoro-6-halophenol as an intermediate; a process for producing a 2-alkoxy-3-fluorophenol and further a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; a second process for producing a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; and a 2-alkoxy-3-fluorophenol. The 2-fluoro-6-halophenol can be obtained using a 2-fluorophenol as a starting material and through a sulfonation reaction, a halogenation reaction, and a deprotection reaction. The 2-fluoro-6-halophenol is alkyl-etherified, and subsequently the halogen atom is converted into a hydroxyl group to obtain the 2-alkoxy-3-fluorophenol, which is further alkyl-etherified to thereby obtain the 1,2-dialkoxy-3-fluorobenzene. Alternatively, a 1,2-dialkoxy-3-fluorobenzene is also obtained by converting the halogen atom of the 2-fluoro-6-halophenol into a hydroxyl group to thereby form 3-fluorocatechol and subsequently alkyl-etherifying two hydroxyl groups thereof. The processes of the invention realize low production costs and high process yields, and thus are suitable for industrial production of a 1,2-dialkoxy-3-fluorobenzene.

Halogen-lithium exchange between substituted dihalobenzenes and butyllithium: Application to the regioselective synthesis of functionalized bromobenzaldehydes

Halogen-lithium interconversion reactions between unsymmetrically substituted mono- and bifunctional dihalobenzenes C6H 3XHal2 and C6H2XYHal2 (Hal=Br, I; X, Y=F, OR, CF3, CH(OMe)2) and butyllithium were investigated. The resultant organolithium intermediates were converted into the corresponding benzaldehydes in moderate to good yields. As a rule, bromine atoms in the position ortho to the functional group were replaced preferentially with lithium. Intramolecular competition experiments with bifunctional systems revealed that fluorine is capable of activating the neighboring bromine atom more strongly than methoxy and dimethoxymethyl groups. On the replacement of the non-activated bromine with iodine a complete reversal of this reactivity pattern can be accomplished due to the preferred iodine-lithium exchange.