2-(6-tert-butoxycarbonylamino-5-hydroxy-2-isopropyl-4-oxo-7-phenyl-3-azaheptanoylamino)-3-phenylpropionic acid benzyl ester

Base Information

Chemical Name:2-(6-tert-butoxycarbonylamino-5-hydroxy-2-isopropyl-4-oxo-7-phenyl-3-azaheptanoylamino)-3-phenylpropionic acid benzyl ester
CAS No.:217480-75-6
Molecular Formula:C₃₆H₄₅N₃O₇
Molecular Weight:631.769
Hs Code.:

Synonyms:2-(6-tert-butoxycarbonylamino-5-hydroxy-2-isopropyl-4-oxo-7-phenyl-3-azaheptanoylamino)-3-phenylpropionic acid benzyl ester

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Chemical Property of 2-(6-tert-butoxycarbonylamino-5-hydroxy-2-isopropyl-4-oxo-7-phenyl-3-azaheptanoylamino)-3-phenylpropionic acid benzyl ester

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Technology Process of 2-(6-tert-butoxycarbonylamino-5-hydroxy-2-isopropyl-4-oxo-7-phenyl-3-azaheptanoylamino)-3-phenylpropionic acid benzyl ester

There total 14 articles about 2-(6-tert-butoxycarbonylamino-5-hydroxy-2-isopropyl-4-oxo-7-phenyl-3-azaheptanoylamino)-3-phenylpropionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1738-78-9
L-phenylalanine benzyl ester p-toluene-sulfonic acid salt

: 612096-24-9
(S)-2-((2S,3R)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyrylamino)-3-methyl-butyric acid

: 217480-75-6
2-(6-tert-butoxycarbonylamino-5-hydroxy-2-isopropyl-4-oxo-7-phenyl-3-azaheptanoylamino)-3-phenylpropionic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1016/S0040-4039(03)01799-4

Reference yield:

: 962-39-0
L-Phenylalanine benzyl ester

: 246506-76-3
6-tert-butoxycarbonylamino-2-isopropyl-4,5-dioxo-7-phenyl-3-azaheptanoic acid benzyl ester

: 217480-75-6
2-(6-tert-butoxycarbonylamino-5-hydroxy-2-isopropyl-4-oxo-7-phenyl-3-azaheptanoylamino)-3-phenylpropionic acid benzyl ester

Guidance literature:: 6-tert-butoxycarbonylamino-2-isopropyl-4,5-dioxo-7-phenyl-3-azaheptanoic acid benzyl ester; With zinc(II) tetrahydroborate; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1h;

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 2h; under 760 Torr;

L-Phenylalanine benzyl ester; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/S0040-4020(03)00860-3

Reference yield:

: 246506-77-4
6-tert-butoxycarbonylamino-5-hydroxy-2-isopropyl-4-oxo-7-phenyl-3-azaheptanoic acid benzyl ester

: 217480-75-6
2-(6-tert-butoxycarbonylamino-5-hydroxy-2-isopropyl-4-oxo-7-phenyl-3-azaheptanoylamino)-3-phenylpropionic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / hydrogen / Pd/C / methanol / 3 h / 20 °C

2: 85 percent / EDAC; HOBt; DIPEA / dimethylformamide; CH₂Cl₂ / 12 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(03)01799-4