6-tert-butoxycarbonylamino-5-hydroxy-2-isopropyl-4-oxo-7-phenyl-3-azaheptanoic acid benzyl ester

Base Information

Chemical Name:6-tert-butoxycarbonylamino-5-hydroxy-2-isopropyl-4-oxo-7-phenyl-3-azaheptanoic acid benzyl ester
CAS No.:246506-77-4
Molecular Formula:C₂₇H₃₆N₂O₆
Molecular Weight:484.593
Hs Code.:

Synonyms:6-tert-butoxycarbonylamino-5-hydroxy-2-isopropyl-4-oxo-7-phenyl-3-azaheptanoic acid benzyl ester

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Chemical Property of 6-tert-butoxycarbonylamino-5-hydroxy-2-isopropyl-4-oxo-7-phenyl-3-azaheptanoic acid benzyl ester

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Technology Process of 6-tert-butoxycarbonylamino-5-hydroxy-2-isopropyl-4-oxo-7-phenyl-3-azaheptanoic acid benzyl ester

There total 10 articles about 6-tert-butoxycarbonylamino-5-hydroxy-2-isopropyl-4-oxo-7-phenyl-3-azaheptanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 16652-76-9
L-valine benzyl ester p-toluenesulfonate salt

: 62023-65-8
(2S,3R)-3-[(tert-butoxycarbonyl) amino]-2-hydroxy-4-phenyl-butanoic acid

: 246506-77-4
6-tert-butoxycarbonylamino-5-hydroxy-2-isopropyl-4-oxo-7-phenyl-3-azaheptanoic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1016/S0040-4039(03)01799-4

Reference yield:

: 246506-76-3
6-tert-butoxycarbonylamino-2-isopropyl-4,5-dioxo-7-phenyl-3-azaheptanoic acid benzyl ester

: 246506-77-4
6-tert-butoxycarbonylamino-5-hydroxy-2-isopropyl-4-oxo-7-phenyl-3-azaheptanoic acid benzyl ester

: 6-tert-butoxycarbonylamino-5-hydroxy-2-isopropyl-4-oxo-7-phenyl-3-azaheptanoic acid benzyl ester

Guidance literature:: With zinc(II) tetrahydroborate; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.5h;
DOI:10.1016/S0040-4039(99)01143-0

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 246506-77-4
6-tert-butoxycarbonylamino-5-hydroxy-2-isopropyl-4-oxo-7-phenyl-3-azaheptanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / hydrogen / Pd/C / ethyl acetate / 5 h / 20 °C

2: 79 percent / Na₂CO₃ / H₂O; methanol / 12 h / 20 °C

3: 87 percent / EDAC; HOBt; DIPEA / dimethylformamide; CH₂Cl₂ / 12 h / 20 °C

With hydrogen; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(03)01799-4