(S)-2-[(S)-2-((2S,3R)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyrylamino)-3-methyl-butyrylamino]-3-phenyl-propionic acid

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Chemical Name:(S)-2-[(S)-2-((2S,3R)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyrylamino)-3-methyl-butyrylamino]-3-phenyl-propionic acid
CAS No.:217480-76-7
Molecular Formula:C₂₉H₃₉N₃O₇
Molecular Weight:541.645
Hs Code.:

Synonyms:(S)-2-[(S)-2-((2S,3R)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyrylamino)-3-methyl-butyrylamino]-3-phenyl-propionic acid

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Chemical Property of (S)-2-[(S)-2-((2S,3R)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyrylamino)-3-methyl-butyrylamino]-3-phenyl-propionic acid

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Technology Process of (S)-2-[(S)-2-((2S,3R)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyrylamino)-3-methyl-butyrylamino]-3-phenyl-propionic acid

There total 14 articles about (S)-2-[(S)-2-((2S,3R)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyrylamino)-3-methyl-butyrylamino]-3-phenyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 217480-75-6
2-(6-tert-butoxycarbonylamino-5-hydroxy-2-isopropyl-4-oxo-7-phenyl-3-azaheptanoylamino)-3-phenylpropionic acid benzyl ester

: 217480-76-7
(S)-2-[(S)-2-((2S,3R)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyrylamino)-3-methyl-butyrylamino]-3-phenyl-propionic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 3h;
DOI:10.1016/S0040-4039(03)01799-4

Reference yield:

: 612096-24-9
(S)-2-((2S,3R)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyrylamino)-3-methyl-butyric acid

: 217480-76-7
(S)-2-[(S)-2-((2S,3R)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyrylamino)-3-methyl-butyrylamino]-3-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / EDAC; HOBt; DIPEA / dimethylformamide; CH₂Cl₂ / 12 h / 20 °C

2: 95 percent / hydrogen / Pd/C / methanol / 3 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(03)01799-4

Reference yield:

: 246506-77-4
6-tert-butoxycarbonylamino-5-hydroxy-2-isopropyl-4-oxo-7-phenyl-3-azaheptanoic acid benzyl ester

: 217480-76-7
(S)-2-[(S)-2-((2S,3R)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyrylamino)-3-methyl-butyrylamino]-3-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / hydrogen / Pd/C / methanol / 3 h / 20 °C

2: 85 percent / EDAC; HOBt; DIPEA / dimethylformamide; CH₂Cl₂ / 12 h / 20 °C

3: 95 percent / hydrogen / Pd/C / methanol / 3 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(03)01799-4