N-{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]benzoyl}glycine ethyl ester

Base Information

Chemical Name:N-{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]benzoyl}glycine ethyl ester
CAS No.:1211472-99-9
Molecular Formula:C₂₈H₃₂N₂O₃
Molecular Weight:444.574
Hs Code.:

Synonyms:N-{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]benzoyl}glycine ethyl ester

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Chemical Property of N-{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]benzoyl}glycine ethyl ester

Chemical Property:

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Technology Process of N-{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]benzoyl}glycine ethyl ester

There total 7 articles about N-{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]benzoyl}glycine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[(1R,3S)-3-{[(1R)-1-(naphthalen-1-yl)ethyl]amino}cyclopentyl]benzoic acid chloride hydrochloride

: 623-33-6
glycine ethyl ester hydrochloride

: 1211472-99-9
N-{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]benzoyl}glycine ethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 5467-74-3
4-Bromophenylboronic acid

: 1211472-99-9
N-{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]benzoyl}glycine ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: bis(ethylene)rhodium acetylacetonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / 1,4-dioxane; water / 3 h / Inert atmosphere; Reflux

2: sodium cyanoborohydride; acetic acid / methanol / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 70 °C / Inert atmosphere

4: potassium hydroxide; water / ethanol; tetrahydrofuran / 20 °C

5: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere

6: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With oxalyl dichloride; water; sodium cyanoborohydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(ethylene)rhodium acetylacetonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 930-30-3
cyclopent-2-enone

: 1211472-99-9
N-{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]benzoyl}glycine ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: bis(ethylene)rhodium acetylacetonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / 1,4-dioxane; water / 3 h / Inert atmosphere; Reflux

2: sodium cyanoborohydride; acetic acid / methanol / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 70 °C / Inert atmosphere

4: potassium hydroxide; water / ethanol; tetrahydrofuran / 20 °C

5: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere

6: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With oxalyl dichloride; water; sodium cyanoborohydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(ethylene)rhodium acetylacetonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;