N-{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]benzoyl}glycine hydrochloride

Base Information

Chemical Name:N-{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]benzoyl}glycine hydrochloride
CAS No.:1211471-80-5
Molecular Formula:C₂₆H₂₈N₂O₃*ClH
Molecular Weight:452.981
Hs Code.:

Synonyms:N-{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]benzoyl}glycine hydrochloride

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Chemical Property of N-{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]benzoyl}glycine hydrochloride

Chemical Property:

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Technology Process of N-{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]benzoyl}glycine hydrochloride

There total 8 articles about N-{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]benzoyl}glycine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1211472-99-9
N-{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]benzoyl}glycine ethyl ester

: 1211471-80-5
N-{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]benzoyl}glycine hydrochloride

Guidance literature:: N-{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]benzoyl}glycine ethyl ester; With water; sodium hydroxide; In ethanol; at 20 ℃; for 4h;

With hydrogenchloride; In ethanol; water;

Reference yield:

: 1211472-82-0
(1S,3R)-3-(4-bromophenyl)-N-[(1R)-1-(naphthalen-1-yl)ethyl]cyclopentanamine

: 1211471-80-5
N-{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]benzoyl}glycine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 70 °C / Inert atmosphere

2: potassium hydroxide; water / ethanol; tetrahydrofuran / 20 °C

3: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

5: sodium hydroxide; water / ethanol / 4 h / 20 °C

With oxalyl dichloride; water; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1211472-97-7
4-[(1R,3S)-3-{[(1R)-1-(naphthalen-1-yl)ethyl]amino}cyclopentyl]benzoic acid hydrochloride

: 1211471-80-5
N-{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]benzoyl}glycine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

3: sodium hydroxide; water / ethanol / 4 h / 20 °C

With oxalyl dichloride; water; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In ethanol; dichloromethane;