glycine, N-[[4-chloro-2-[[7-methoxy-6-[2-[[2-(4-morpholinyl)ethyl]amino]ethoxy]-4-quinazolinyl]amino]phenyl]acetyl]-

Base Information

Chemical Name:glycine, N-[[4-chloro-2-[[7-methoxy-6-[2-[[2-(4-morpholinyl)ethyl]amino]ethoxy]-4-quinazolinyl]amino]phenyl]acetyl]-
CAS No.:890532-46-4
Molecular Formula:C₂₇H₃₃ClN₆O₆
Molecular Weight:573.049
Hs Code.:

Synonyms:glycine, N-[[4-chloro-2-[[7-methoxy-6-[2-[[2-(4-morpholinyl)ethyl]amino]ethoxy]-4-quinazolinyl]amino]phenyl]acetyl]-

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Chemical Property of glycine, N-[[4-chloro-2-[[7-methoxy-6-[2-[[2-(4-morpholinyl)ethyl]amino]ethoxy]-4-quinazolinyl]amino]phenyl]acetyl]-

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Technology Process of glycine, N-[[4-chloro-2-[[7-methoxy-6-[2-[[2-(4-morpholinyl)ethyl]amino]ethoxy]-4-quinazolinyl]amino]phenyl]acetyl]-

There total 8 articles about glycine, N-[[4-chloro-2-[[7-methoxy-6-[2-[[2-(4-morpholinyl)ethyl]amino]ethoxy]-4-quinazolinyl]amino]phenyl]acetyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: glycine, N-[[4-chloro-2-[[7-methoxy-6-[2-[[2-(4-morpholinyl)ethyl]amino]ethoxy]-4-quinazolinyl]amino]phenyl]acetyl]-, ethyl ester

: 890532-46-4
glycine, N-[[4-chloro-2-[[7-methoxy-6-[2-[[2-(4-morpholinyl)ethyl]amino]ethoxy]-4-quinazolinyl]amino]phenyl]acetyl]-

Guidance literature:: With lithium hydroxide; ethanol; water; at 20 ℃; for 2h;

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 890532-46-4
glycine, N-[[4-chloro-2-[[7-methoxy-6-[2-[[2-(4-morpholinyl)ethyl]amino]ethoxy]-4-quinazolinyl]amino]phenyl]acetyl]-

Guidance literature:: Multi-step reaction with 5 steps

1.1: isopropyl alcohol / 16 h / 80 °C

2.1: methanol; ammonia / 20 °C

3.1: caesium carbonate / DMF (N,N-dimethyl-formamide) / 0.5 h / 20 °C

3.2: 20 °C

4.1: ethanol / 1.5 h / 100 °C / heated in a microwave

5.1: lithium hydroxide; water / ethanol / 2 h / 20 °C

With methanol; lithium hydroxide; ammonia; water; caesium carbonate; In DMF (N,N-dimethyl-formamide); ethanol; isopropyl alcohol;

Reference yield:

: 807640-16-0
glycine, N-[ (4-chloro-2-nitrophenyl) acetyl]-, ethyl ester

: 890532-46-4
glycine, N-[[4-chloro-2-[[7-methoxy-6-[2-[[2-(4-morpholinyl)ethyl]amino]ethoxy]-4-quinazolinyl]amino]phenyl]acetyl]-

Guidance literature:: Multi-step reaction with 6 steps

1.1: thiophene; hydrogen / platinum on activated charcoal / tetrahydrofuran

2.1: isopropyl alcohol / 16 h / 80 °C

3.1: methanol; ammonia / 20 °C

4.1: caesium carbonate / DMF (N,N-dimethyl-formamide) / 0.5 h / 20 °C

4.2: 20 °C

5.1: ethanol / 1.5 h / 100 °C / heated in a microwave

6.1: lithium hydroxide; water / ethanol / 2 h / 20 °C

With thiophene; methanol; lithium hydroxide; ammonia; water; hydrogen; caesium carbonate; platinum on activated charcoal; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); ethanol; isopropyl alcohol;