glycine, N-[[2-[[6-(2-bromoethoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-, ethyl ester

Base Information

Chemical Name:glycine, N-[[2-[[6-(2-bromoethoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-, ethyl ester
CAS No.:807640-25-1
Molecular Formula:C₂₃H₂₄BrClN₄O₅
Molecular Weight:551.824
Hs Code.:

Synonyms:glycine, N-[[2-[[6-(2-bromoethoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-, ethyl ester

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Chemical Property of glycine, N-[[2-[[6-(2-bromoethoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-, ethyl ester

Chemical Property:

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Technology Process of glycine, N-[[2-[[6-(2-bromoethoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-, ethyl ester

There total 6 articles about glycine, N-[[2-[[6-(2-bromoethoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: glycine, N-[[4-chloro-2-[(6-hydroxy-7-methoxy-4-quinazolinyl)amino]phenyl]acetyl]-, ethyl ester

: 106-93-4
ethylene dibromide

: 807640-25-1
glycine, N-[[2-[[6-(2-bromoethoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-, ethyl ester

Guidance literature:: glycine, N-[[4-chloro-2-[(6-hydroxy-7-methoxy-4-quinazolinyl)amino]phenyl]acetyl]-, ethyl ester; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

ethylene dibromide; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 807640-25-1
glycine, N-[[2-[[6-(2-bromoethoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-, ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropyl alcohol / 16 h / 80 °C

2.1: methanol; ammonia / 20 °C

3.1: caesium carbonate / DMF (N,N-dimethyl-formamide) / 0.5 h / 20 °C

3.2: 20 °C

With methanol; ammonia; caesium carbonate; In DMF (N,N-dimethyl-formamide); isopropyl alcohol;

Reference yield:

: 807640-16-0
glycine, N-[ (4-chloro-2-nitrophenyl) acetyl]-, ethyl ester

: 807640-25-1
glycine, N-[[2-[[6-(2-bromoethoxy)-7-methoxy-4-quinazolinyl]amino]-4-chlorophenyl]acetyl]-, ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: thiophene; hydrogen / platinum on activated charcoal / tetrahydrofuran

2.1: isopropyl alcohol / 16 h / 80 °C

3.1: methanol; ammonia / 20 °C

4.1: caesium carbonate / DMF (N,N-dimethyl-formamide) / 0.5 h / 20 °C

4.2: 20 °C

With thiophene; methanol; ammonia; hydrogen; caesium carbonate; platinum on activated charcoal; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); isopropyl alcohol;