(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid isopropyl ester

Base Information

Chemical Name:(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid isopropyl ester
CAS No.:362477-14-3
Molecular Formula:C₂₇H₃₁N₂O₅P
Molecular Weight:494.527
Hs Code.:

(3-benzyloxycarbamoyl-3,4-dihydro-1<i>H</i>-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid isopropyl ester

Synonyms:(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid isopropyl ester

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Chemical Property of (3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid isopropyl ester

Chemical Property:

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Technology Process of (3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid isopropyl ester

There total 4 articles about (3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₀H₁₄ClO₃P

: 404001-44-1
(3R)-N-benzyloxy-1,2,3,4-tetrahydroisoquinoline-3-hydroxamide

: 362477-14-3
(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid isopropyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm0103211

Reference yield:

: 622-33-3
N-benzyloxyamine

: 362477-14-3
(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid isopropyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 41 percent / WSC; HOBt; triethylamine / dimethylformamide / 20 °C

2: 4.6 g / 4N HCl / ethyl acetate / 2 h / 20 °C

3: diisopropylethylamine / tetrahydrofuran / 20 °C

With hydrogenchloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm0103211

Reference yield:

: 41220-48-8
(3R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride

: 362477-14-3
(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid isopropyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 61 percent / aq. sodium carbonate / dioxane / 20 °C

2: 41 percent / WSC; HOBt; triethylamine / dimethylformamide / 20 °C

3: 4.6 g / 4N HCl / ethyl acetate / 2 h / 20 °C

4: diisopropylethylamine / tetrahydrofuran / 20 °C

With hydrogenchloride; sodium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm0103211