N-(3-bromophenyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-(3-bromophenyl)-4-methylbenzenesulfonamide
• CAS No.: 7510-48-7
• Molecular Formula: C13H12 Br N O2 S
• Molecular Weight: 326.214
• Mol file: 7510-48-7.mol

Synonyms:p-Toluenesulfonanilide,3'-bromo- (8CI); NSC 405688

Chemical Property of N-(3-bromophenyl)-4-methylbenzenesulfonamide

Chemical Property:

• Vapor Pressure: 1.38E-07mmHg at 25°C
• Boiling Point: 429.7°Cat760mmHg
• Flash Point: 213.7°C
• Density: 1.545g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(3-bromophenyl)-4-methylbenzenesulfonamide

There total 6 articles about N-(3-bromophenyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

p-toluenesulfonyl chloride (98-59-9) + m-Bromoaniline (591-19-5) → N-(3-bromophenyl)-4-methyl-benzenesulfonamide (7510-48-7)

Guidance literature:

With pyridine; for 0.333333h; Heating;

DOI:10.1021/jo990983m

Reference yield: 80.0%

m-nitrobromobenzene (585-79-5) + sodium 4-methylbenzenesulfinate (824-79-3) → N-(3-bromophenyl)-4-methyl-benzenesulfonamide (7510-48-7)

Guidance literature:

m-nitrobromobenzene; With tetrahydroxydiboron; In methanol; water; at 100 ℃; for 8h; Schlenk technique;

sodium 4-methylbenzenesulfinate; With iodine; In methanol; water; at 35 ℃; for 3h; Schlenk technique;

DOI:10.1016/j.tetlet.2020.152397

Reference yield: 57.0%

m-nitrobromobenzene (585-79-5) + 1-(4'-methylbenzenesulfonyl)-1H-benzo[d][1.2.3]triazole (1028-19-9) → N-(3-bromophenyl)-4-methyl-benzenesulfonamide (7510-48-7)

Guidance literature:

With chloro-trimethyl-silane; (1,2-dimethoxyethane)dichloronickel(II); bathophenanthroline; zinc; In 1,4-dioxane; at 100 ℃; for 15h; Schlenk technique; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.1c03535

upstream raw materials:

p-toluenesulfonyl chloride

m-Bromoaniline

m-nitrobromobenzene

sodium 4-methylbenzenesulfinate

Downstream raw materials:

4-methyl-N-(3-octylphenyl) benzenesulfonamide

N-(5-bromo-2-nitrophenyl)-4-methylbenzenesulfonamide

N-(3-bromo-4-nitrophenyl)-4-methylbenzenesulfonamide

4-bromo-3-[(E)-phenylmethylidene]-1-tosylindoline

Refernces

• 1、 Qu, Erdong,Li, Shangzhang,Bai, Jin,Zheng, Yan,Li, Wanfang. "Nickel-Catalyzed Reductive Cross-Coupling of N-Acyl and N-Sulfonyl Benzotriazoles with Diverse Nitro Compounds: Rapid Access to Amides and Sulfonamides". supporting information. p. 58 - 63. Retrieved 2021/12/27.
• 2、 Youn, So Won,Kim, Young Ho,Jo, Yoon Hyung. "Palladium-Catalyzed Regioselective Synthesis of 1-Hydroxycarbazoles Under Aerobic Conditions". supporting information. p. 462 - 468. Retrieved 2019/01/04.