(3R,5S)-3-[2,6-dichloro-4-(4,4-difluoropiperidine-1-carbonyl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Base Information

Chemical Name:(3R,5S)-3-[2,6-dichloro-4-(4,4-difluoropiperidine-1-carbonyl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one
CAS No.:955407-59-7
Molecular Formula:C₂₄H₂₆Cl₂F₂N₄O₂
Molecular Weight:511.399
Hs Code.:

Synonyms:(3R,5S)-3-[2,6-dichloro-4-(4,4-difluoropiperidine-1-carbonyl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

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Chemical Property of (3R,5S)-3-[2,6-dichloro-4-(4,4-difluoropiperidine-1-carbonyl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

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Technology Process of (3R,5S)-3-[2,6-dichloro-4-(4,4-difluoropiperidine-1-carbonyl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

There total 11 articles about (3R,5S)-3-[2,6-dichloro-4-(4,4-difluoropiperidine-1-carbonyl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₅Cl₂F₅N₄O₄S

: 955407-59-7
(3R,5S)-3-[2,6-dichloro-4-(4,4-difluoropiperidine-1-carbonyl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Guidance literature:: With lithium hydroxide; water; In 1,2-dimethoxyethane; at 20 ℃; for 2h;

Reference yield:

: 1171130-67-8
(3-dimethylaminomethylene-4-oxo-cyclohexyl)-carbamic acid tert-butyl ester

: 955407-59-7
(3R,5S)-3-[2,6-dichloro-4-(4,4-difluoropiperidine-1-carbonyl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrazine / ethanol / 20 °C

2.1: methanol; hexanes / Resolution of racemate

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

4.1: 1,2-dichloro-ethane; isopropyl alcohol / 17 h / 20 °C

4.2: 2 h / 20 °C

4.3: 1 h / 20 °C

5.1: hydrogen / palladium dihydroxide / ethanol / 6 h / 1551.49 Torr

6.1: pyridine / 3.01 h / 0 - 20 °C

7.1: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 9 h / 80 - 85 °C / 2068.65 - 2585.81 Torr

8.1: lithium hydroxide; water / 1,2-dimethoxyethane / 2 h / 20 °C

With pyridine; lithium hydroxide; water; hydrogen; triethylamine; trifluoroacetic acid; hydrazine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium dihydroxide; In methanol; hexanes; 1,2-dimethoxyethane; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 955373-73-6
(R)-4-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-benzyloxy-2,6-dichloro-benzyl)-4-oxo-butyraldehyde

: 955407-59-7
(3R,5S)-3-[2,6-dichloro-4-(4,4-difluoropiperidine-1-carbonyl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,2-dichloro-ethane; isopropyl alcohol / 17 h / 20 °C

1.2: 2 h / 20 °C

1.3: 1 h / 20 °C

2.1: hydrogen / palladium dihydroxide / ethanol / 6 h / 1551.49 Torr

3.1: pyridine / 3.01 h / 0 - 20 °C

4.1: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 9 h / 80 - 85 °C / 2068.65 - 2585.81 Torr

5.1: lithium hydroxide; water / 1,2-dimethoxyethane / 2 h / 20 °C

With pyridine; lithium hydroxide; water; hydrogen; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium dihydroxide; In 1,2-dimethoxyethane; ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol;