Technology Process of (3-(N-hydroxyacetamido)-1-(4-morpholinophenyl)-propyl)phosphonic acid
There total 8 articles about (3-(N-hydroxyacetamido)-1-(4-morpholinophenyl)-propyl)phosphonic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trimethylsilyl bromide;
In
dichloromethane;
at 20 ℃;
for 7h;
Inert atmosphere;
DOI:10.1021/jo201715x
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 2.9-dimethyl-1,10-phenanthroline; palladium diacetate; p-benzoquinone / acetonitrile / 24 h / 20 °C
2.1: 3 h / 100 °C
3.1: hydrogenchloride; water / acetone / 26 h / Reflux
4.1: pyridine / ethanol / 5 h
5.1: sodium cyanoborohydride / methanol / 20 °C
5.2: 0 °C / Cooling with ice
6.1: triethylamine / dichloromethane / 1.5 h
7.1: bis-triphenylphosphine-palladium(II) chloride; sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate / toluene / 0.5 h / 100 °C / Microwave irradiation; Sealed tube; Inert atmosphere
8.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 760.05 Torr
9.1: trimethylsilyl bromide / dichloromethane / 7 h / 20 °C / Inert atmosphere
With
pyridine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; 2.9-dimethyl-1,10-phenanthroline; trimethylsilyl bromide; palladium 10% on activated carbon; water; hydrogen; palladium diacetate; sodium cyanoborohydride; triethylamine; p-benzoquinone; sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate;
In
methanol; ethanol; dichloromethane; acetone; toluene; acetonitrile;
1.1: Heck reaction;
DOI:10.1021/jo201715x
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydrogenchloride; water / acetone / 26 h / Reflux
2.1: pyridine / ethanol / 5 h
3.1: sodium cyanoborohydride / methanol / 20 °C
3.2: 0 °C / Cooling with ice
4.1: triethylamine / dichloromethane / 1.5 h
5.1: bis-triphenylphosphine-palladium(II) chloride; sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate / toluene / 0.5 h / 100 °C / Microwave irradiation; Sealed tube; Inert atmosphere
6.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 760.05 Torr
7.1: trimethylsilyl bromide / dichloromethane / 7 h / 20 °C / Inert atmosphere
With
pyridine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; trimethylsilyl bromide; palladium 10% on activated carbon; water; hydrogen; sodium cyanoborohydride; triethylamine; sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate;
In
methanol; ethanol; dichloromethane; acetone; toluene;
DOI:10.1021/jo201715x
