diethyl (3-(N-(benzyloxy)acetamido)-1-(4-morpholino-phenyl)propyl)phosphonate

Base Information

Chemical Name:diethyl (3-(N-(benzyloxy)acetamido)-1-(4-morpholino-phenyl)propyl)phosphonate
CAS No.:1339075-40-9
Molecular Formula:C₂₆H₃₇N₂O₆P
Molecular Weight:504.563
Hs Code.:

Synonyms:diethyl (3-(N-(benzyloxy)acetamido)-1-(4-morpholino-phenyl)propyl)phosphonate

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Chemical Property of diethyl (3-(N-(benzyloxy)acetamido)-1-(4-morpholino-phenyl)propyl)phosphonate

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Technology Process of diethyl (3-(N-(benzyloxy)acetamido)-1-(4-morpholino-phenyl)propyl)phosphonate

There total 9 articles about diethyl (3-(N-(benzyloxy)acetamido)-1-(4-morpholino-phenyl)propyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 110-91-8,99108-56-2
morpholine

: 1339075-26-1
diethyl (3-(N-(benzyloxy)acetamido)-1-(4-bromophenyl)-propyl)phosphonate

: 75-36-5
acetyl chloride

: 1339075-40-9
diethyl (3-(N-(benzyloxy)acetamido)-1-(4-morpholino-phenyl)propyl)phosphonate

Guidance literature:: morpholine; diethyl (3-(N-(benzyloxy)acetamido)-1-(4-bromophenyl)-propyl)phosphonate; With bis-triphenylphosphine-palladium(II) chloride; sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate; In toluene; at 100 ℃; for 0.5h; Microwave irradiation; Sealed tube; Inert atmosphere;

acetyl chloride; With triethylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jo201715x

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 1339075-26-1
diethyl (3-(N-(benzyloxy)acetamido)-1-(4-bromophenyl)-propyl)phosphonate

: C₂₄H₃₅N₂O₅P

: 1339075-40-9
diethyl (3-(N-(benzyloxy)acetamido)-1-(4-morpholino-phenyl)propyl)phosphonate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate; In toluene; at 100 ℃; for 0.5h; Microwave irradiation; Sealed tube; Inert atmosphere;
DOI:10.1021/jo201715x

Reference yield:

: 5467-74-3
4-Bromophenylboronic acid

: 1339075-40-9
diethyl (3-(N-(benzyloxy)acetamido)-1-(4-morpholino-phenyl)propyl)phosphonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 2.9-dimethyl-1,10-phenanthroline; palladium diacetate; p-benzoquinone / acetonitrile / 24 h / 20 °C

2.1: 3 h / 100 °C

3.1: hydrogenchloride; water / acetone / 26 h / Reflux

4.1: pyridine / ethanol / 5 h

5.1: sodium cyanoborohydride / methanol / 20 °C

5.2: 0 °C / Cooling with ice

6.1: triethylamine / dichloromethane / 1.5 h

7.1: bis-triphenylphosphine-palladium(II) chloride; sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate / toluene / 0.5 h / 100 °C / Microwave irradiation; Sealed tube; Inert atmosphere

With pyridine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; 2.9-dimethyl-1,10-phenanthroline; water; palladium diacetate; sodium cyanoborohydride; triethylamine; p-benzoquinone; sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate; In methanol; ethanol; dichloromethane; acetone; toluene; acetonitrile; 1.1: Heck reaction;
DOI:10.1021/jo201715x