methyl 1-(phenylsulfonyl)-1H-indole-2-carboxylate

Base Information

• Chemical Name: methyl 1-(phenylsulfonyl)-1H-indole-2-carboxylate
• CAS No.: 60376-48-9
• Molecular Formula: C₁₆H₁₃NO₄S
• Molecular Weight: 315.35
• Mol file: 60376-48-9.mol

Synonyms:methyl 1-(phenylsulfonyl)-1H-indole-2-carboxylate

Chemical Property of methyl 1-(phenylsulfonyl)-1H-indole-2-carboxylate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Methyl 1-(phenylsulfonyl)-1H-indole-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 1-(phenylsulfonyl)-1H-indole-2-carboxylate

There total 4 articles about methyl 1-(phenylsulfonyl)-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

indole-2-carboxylic acid methyl ester (1202-04-6) + benzenesulfonyl chloride (98-09-9) → methyl 1-(phenylsulfonyl)-1H-indole-2-carboxylate (60376-48-9)

Guidance literature:

With potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In benzene; for 0.5h; Ambient temperature;

DOI:10.1021/ja00229a039

Reference yield:

Indole-2-carboxylic acid (1477-50-5,1228050-17-6) → methyl 1-(phenylsulfonyl)-1H-indole-2-carboxylate (60376-48-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere; Cooling with ice

With sodium hydride; sodium hydrogencarbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2011.10.022

Reference yield:

1-benzenesulfonylindole (40899-71-6) → methyl 1-(phenylsulfonyl)-1H-indole-2-carboxylate (60376-48-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) (i-Pr₂N)2Mg / 1.) THF, r.t.

With magnesium bis(N,N-diisopropylamide);

DOI:10.1039/p19960002331

upstream raw materials:

indole-2-carboxylic acid methyl ester

benzenesulfonyl chloride

diazomethane

1-(phenylsulfonyl)-1H-indole-2-carboxylic acid

Downstream raw materials:

indole-2-carboxylic acid methyl ester

1-methyl-4-(phenyl-sulfonyl)-1H-furo[3,4-b]indol-3(4H)-one

C₁₉H₂₁N₃O₄S

C₂₂H₂₇N₃O₄S

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