3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-(methylthio)pyrazolo[5,1-b][1,3]thiazole

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Chemical Name:3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-(methylthio)pyrazolo[5,1-b][1,3]thiazole
CAS No.:1290128-02-7
Molecular Formula:C₁₆H₁₈N₂O₃S₂
Molecular Weight:350.463
Hs Code.:

Synonyms:3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-(methylthio)pyrazolo[5,1-b][1,3]thiazole

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Chemical Property of 3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-(methylthio)pyrazolo[5,1-b][1,3]thiazole

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Technology Process of 3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-(methylthio)pyrazolo[5,1-b][1,3]thiazole

There total 7 articles about 3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-(methylthio)pyrazolo[5,1-b][1,3]thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1290128-01-6
3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-(methylsulfonyl)pyrazolo[5,1-b][1,3]thiazole

: 1290128-02-7
3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-(methylthio)pyrazolo[5,1-b][1,3]thiazole

Guidance literature:: 3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-(methylsulfonyl)pyrazolo[5,1-b][1,3]thiazole; With lithium aluminium tetrahydride; titanium tetrachloride; In tetrahydrofuran; at -78 - 50 ℃; for 2h;

With sodium hydroxide; In tetrahydrofuran; water; Cooling with ice;

Reference yield:

: 1290128-06-1
2-bromo-1-[2,6-dimethoxy-4-(methoxymethyl)phenyl]ethanone

: 1290128-02-7
3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-(methylthio)pyrazolo[5,1-b][1,3]thiazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium sulfide / N,N-dimethyl-formamide / 2 h / 90 °C

1.2: 2 h / 20 °C

2.1: hydrogenchloride / isopropyl alcohol; water / 20 h / Reflux

3.1: sodium hydroxide; water / ethanol / 2 h / Reflux

3.2: Cooling with ice

4.1: hydrogenchloride / 1,4-dioxane; water / 13 h / Reflux

5.1: L-proline; sodium hydroxide; copper(l) iodide / dimethyl sulfoxide / 3 h / 140 °C / Microwave irradiation

6.1: lithium aluminium tetrahydride; titanium tetrachloride / tetrahydrofuran / 2 h / -78 - 50 °C

6.2: Cooling with ice

With hydrogenchloride; sodium sulfide; copper(l) iodide; lithium aluminium tetrahydride; water; titanium tetrachloride; L-proline; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1290127-99-9
6-bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole-7-carboxylic acid

: 1290128-02-7
3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-(methylthio)pyrazolo[5,1-b][1,3]thiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 1,4-dioxane; water / 13 h / Reflux

2.1: L-proline; sodium hydroxide; copper(l) iodide / dimethyl sulfoxide / 3 h / 140 °C / Microwave irradiation

3.1: lithium aluminium tetrahydride; titanium tetrachloride / tetrahydrofuran / 2 h / -78 - 50 °C

3.2: Cooling with ice

With hydrogenchloride; copper(l) iodide; lithium aluminium tetrahydride; titanium tetrachloride; L-proline; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide;