(2E,3E)-dimethyl 2-((dimethylamino)methylene)-3-(2-(2-fluorophenyl)-2-oxoethylidene)succinate

Base Information

• Chemical Name: (2E,3E)-dimethyl 2-((dimethylamino)methylene)-3-(2-(2-fluorophenyl)-2-oxoethylidene)succinate
• CAS No.: 1380520-63-7
• Molecular Formula: C₁₇H₁₈FNO₅
• Molecular Weight: 335.332
• Mol file: 1380520-63-7.mol

Synonyms:(2E,3E)-dimethyl 2-((dimethylamino)methylene)-3-(2-(2-fluorophenyl)-2-oxoethylidene)succinate

Chemical Property of (2E,3E)-dimethyl 2-((dimethylamino)methylene)-3-(2-(2-fluorophenyl)-2-oxoethylidene)succinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E,3E)-dimethyl 2-((dimethylamino)methylene)-3-(2-(2-fluorophenyl)-2-oxoethylidene)succinate

There total 1 articles about (2E,3E)-dimethyl 2-((dimethylamino)methylene)-3-(2-(2-fluorophenyl)-2-oxoethylidene)succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(E)-3-(N,N-dimethylamino)-1-(2'-fluorophenyl)prop-2-en-1-one (138716-19-5) + dimethyl acetylenedicarboxylate (762-42-5) → (2E,3E)-dimethyl 2-((dimethylamino)methylene)-3-(2-(2-fluorophenyl)-2-oxoethylidene)succinate (1380520-63-7)

Guidance literature:

In acetonitrile; at 100 ℃; for 0.25h; Microwave irradiation;

DOI:10.1016/j.tet.2012.04.013

Reference yield: 76.0%

(2E,3E)-dimethyl 2-((dimethylamino)methylene)-3-(2-(2-fluorophenyl)-2-oxoethylidene)succinate (1380520-63-7) → dimethyl 6-(2-fluorophenyl)pyridine-3,4-dicarboxylate (1380520-72-8)

Guidance literature:

With ammonium acetate; In methanol; at 20 ℃; for 48h;

DOI:10.1016/j.tet.2012.04.013

Reference yield: 72.0%

(2E,3E)-dimethyl 2-((dimethylamino)methylene)-3-(2-(2-fluorophenyl)-2-oxoethylidene)succinate (1380520-63-7) → 2-(2-fluorophenyl)-4,5-bis(methoxycarbonyl)pyridine 1-oxide (1380520-90-0)

Guidance literature:

With hydroxylamine hydrochloride; In methanol; at 20 ℃; for 4h;

DOI:10.1016/j.tet.2012.04.013

upstream raw materials:

(E)-3-(N,N-dimethylamino)-1-(2'-fluorophenyl)prop-2-en-1-one

dimethyl acetylenedicarboxylate

Downstream raw materials:

dimethyl 6-(2-fluorophenyl)pyridine-3,4-dicarboxylate

2-(2-fluorophenyl)-4,5-bis(methoxycarbonyl)pyridine 1-oxide