tert-butyl (2-(5-oxo-5-((3-(6-[4-(trifluoromethyl)phenyl]-1,2,4,5-tetrazin-3-yl)phenyl)amino)pentanamido)ethyl)carbamate

Base Information

Chemical Name:tert-butyl (2-(5-oxo-5-((3-(6-[4-(trifluoromethyl)phenyl]-1,2,4,5-tetrazin-3-yl)phenyl)amino)pentanamido)ethyl)carbamate
CAS No.:1353958-50-5
Molecular Formula:C₂₇H₃₀F₃N₇O₄
Molecular Weight:573.575
Hs Code.:

Synonyms:tert-butyl (2-(5-oxo-5-((3-(6-[4-(trifluoromethyl)phenyl]-1,2,4,5-tetrazin-3-yl)phenyl)amino)pentanamido)ethyl)carbamate

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Chemical Property of tert-butyl (2-(5-oxo-5-((3-(6-[4-(trifluoromethyl)phenyl]-1,2,4,5-tetrazin-3-yl)phenyl)amino)pentanamido)ethyl)carbamate

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Technology Process of tert-butyl (2-(5-oxo-5-((3-(6-[4-(trifluoromethyl)phenyl]-1,2,4,5-tetrazin-3-yl)phenyl)amino)pentanamido)ethyl)carbamate

There total 7 articles about tert-butyl (2-(5-oxo-5-((3-(6-[4-(trifluoromethyl)phenyl]-1,2,4,5-tetrazin-3-yl)phenyl)amino)pentanamido)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 57260-73-8
N-BOC-1,2-diaminoethane

: 1353958-49-2
5-oxo-5-(3-(6-[4-(trifluoromethyl)phenyl]-1,2,4,5-tetrazin-3-yl)phenylamino)pentanoic acid

: 1353958-50-5
tert-butyl (2-(5-oxo-5-((3-(6-[4-(trifluoromethyl)phenyl]-1,2,4,5-tetrazin-3-yl)phenyl)amino)pentanamido)ethyl)carbamate

Guidance literature:: With HATU; In N,N-dimethyl-formamide; for 20h; Inert atmosphere;
DOI:10.1021/ja209325n

Reference yield:

: 329-15-7
4-trifluoromethyl-phenyl acetyl chloride

: 1353958-50-5
tert-butyl (2-(5-oxo-5-((3-(6-[4-(trifluoromethyl)phenyl]-1,2,4,5-tetrazin-3-yl)phenyl)amino)pentanamido)ethyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

2.1: phosphorus pentachloride / 1,2-dichloro-ethane / 24 h / Inert atmosphere; Reflux

3.1: potassium carbonate; hydrazine hydrate / acetonitrile / 25 h / Reflux

3.2: 3 h / 0 °C

4.1: palladium 10% on activated carbon; hydrogen / ethanol / 12 h

5.1: tetrahydrofuran / 4 h / 80 °C / Inert atmosphere

6.1: HATU / N,N-dimethyl-formamide / 20 h / Inert atmosphere

With phosphorus pentachloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja209325n

Reference yield:

: 1203256-54-5
3-nitro-2-[(trifluoromethyl)benzoyl] hydrazide

: 1353958-50-5
tert-butyl (2-(5-oxo-5-((3-(6-[4-(trifluoromethyl)phenyl]-1,2,4,5-tetrazin-3-yl)phenyl)amino)pentanamido)ethyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: phosphorus pentachloride / 1,2-dichloro-ethane / 24 h / Inert atmosphere; Reflux

2.1: potassium carbonate; hydrazine hydrate / acetonitrile / 25 h / Reflux

2.2: 3 h / 0 °C

3.1: palladium 10% on activated carbon; hydrogen / ethanol / 12 h

4.1: tetrahydrofuran / 4 h / 80 °C / Inert atmosphere

5.1: HATU / N,N-dimethyl-formamide / 20 h / Inert atmosphere

With phosphorus pentachloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; hydrazine hydrate; HATU; In tetrahydrofuran; ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja209325n