4,5-dihydro-2-(4,5-dihydro-4,4-dimethyloxazol-2-yl)-4,4-dimethyl-oxazole

Base Information

• Chemical Name: 4,5-dihydro-2-(4,5-dihydro-4,4-dimethyloxazol-2-yl)-4,4-dimethyl-oxazole
• CAS No.: 49585-66-2
• Molecular Formula: C₁₀H₁₆N₂O₂
• Molecular Weight: 196.249
• Mol file: 49585-66-2.mol

Synonyms:4,5-dihydro-2-(4,5-dihydro-4,4-dimethyloxazol-2-yl)-4,4-dimethyl-oxazole

Chemical Property of 4,5-dihydro-2-(4,5-dihydro-4,4-dimethyloxazol-2-yl)-4,4-dimethyl-oxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,5-dihydro-2-(4,5-dihydro-4,4-dimethyloxazol-2-yl)-4,4-dimethyl-oxazole

There total 2 articles about 4,5-dihydro-2-(4,5-dihydro-4,4-dimethyloxazol-2-yl)-4,4-dimethyl-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4,5-dihydro-4,4-dimethyl-2-phenoxazole (19312-06-2) + (S,Z)-6-[(tert-butyldimethylsilyl)oxy]-1-phenylhex-4-en-3-yl pyridine-2-carboxylate (1016652-32-6) → (R,E)-1-[(tert-butyldimethylsilyl)oxy]-2-[2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl]-6-phenylhex-3-ene (1207609-74-2) + 4,5-dihydro-2-(4,5-dihydro-4,4-dimethyloxazol-2-yl)-4,4-dimethyl-oxazole (49585-66-2)

Guidance literature:

4,5-dihydro-4,4-dimethyl-2-phenoxazole; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h;

With copper(I) bromide dimethylsulfide complex; magnesium bromide; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h;

(S,Z)-6-[(tert-butyldimethylsilyl)oxy]-1-phenylhex-4-en-3-yl pyridine-2-carboxylate; In tetrahydrofuran; hexane; at 0 ℃; for 1h; regiospecific reaction;

DOI:10.1016/j.tet.2009.11.052

Reference yield: 94.0%

4,5-dihydro-4,4-dimethyl-2-phenoxazole (19312-06-2) + (S,Z)-6-[(tert-butyldimethylsilyl)oxy]-1-phenylhex-4-en-3-yl pyridine-2-carboxylate (1016652-32-6) → C23H27NO2 (1207609-85-5) + 4,5-dihydro-2-(4,5-dihydro-4,4-dimethyloxazol-2-yl)-4,4-dimethyl-oxazole (49585-66-2)

Guidance literature:

4,5-dihydro-4,4-dimethyl-2-phenoxazole; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h;

With copper(I) bromide dimethylsulfide complex; magnesium bromide; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h;

(S,Z)-6-[(tert-butyldimethylsilyl)oxy]-1-phenylhex-4-en-3-yl pyridine-2-carboxylate; optical yield given as %ee; regiospecific reaction; Further stages;

DOI:10.1016/j.tet.2009.11.052

Reference yield: 40.0%

iodomesitylene (4028-63-1) + nickel(II) bromide 2-methoxyethyl ether complex + (1-chloroethyl)benzene (672-65-1) + 4,5-dihydro-2-(4,5-dihydro-4,4-dimethyloxazol-2-yl)-4,4-dimethyl-oxazole (49585-66-2) → [NiBr((CH3)3C6H2)((CH3)2CCH2OCN)2] (233748-19-1) + 2,3-diphenylbutane (4613-11-0,1245924-68-8) + ((2S,3S)-butane-2,3-diyl)dibenzene (1857-74-5,2726-21-8,4539-34-8,4613-11-0,5789-35-5,71606-46-7)

Guidance literature:

With manganese; chloro-trimethyl-silane; In 1,4-dioxane; at 22 ℃; for 14h; Reagent/catalyst; Time;

DOI:10.1021/jacs.1c07139

upstream raw materials:

4,5-dihydro-4,4-dimethyl-2-phenoxazole

(S,Z)-6-[(tert-butyldimethylsilyl)oxy]-1-phenylhex-4-en-3-yl pyridine-2-carboxylate

Downstream raw materials:

[NiBr((CH₃)3C₆H₂)((CH₃)2CCH₂OCN)2]

2,3-diphenylbutane

((2S,3S)-butane-2,3-diyl)dibenzene