Technology Process of N-[2-(3,5-difluorophenyl)-1-phenylethyl]-4,5-dihydro-1H-imidazol-2-amine formate
There total 3 articles about N-[2-(3,5-difluorophenyl)-1-phenylethyl]-4,5-dihydro-1H-imidazol-2-amine formate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(3,5-difluorophenyl)-1-phenylethanamine hydrochloride; 4,5-dihydro-1H-imidazole-2-sulfonic acid;
With
triethylamine;
In
isopropyl alcohol;
at 140 ℃;
for 0.166667h;
formic acid;
In
water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C
1.2: 10 h / 20 °C
1.3: 0 °C
2.1: hydroxylamine hydrochloride; sodium acetate / methanol / 1 h / Heating / reflux
2.2: 20 °C
2.3: 0.5 h
3.1: triethylamine / isopropyl alcohol / 0.17 h / 140 °C
3.2: SunFire.(TM). Prep C 18
With
thionyl chloride; hydroxylamine hydrochloride; sodium acetate; triethylamine;
N,N-dimethyl-formamide;
In
methanol; dichloromethane; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C
1.2: 10 h / 20 °C
1.3: 0 °C
2.1: hydroxylamine hydrochloride; sodium acetate / methanol / 1 h / Heating / reflux
2.2: 20 °C
2.3: 0.5 h
3.1: triethylamine / isopropyl alcohol / 0.17 h / 140 °C
3.2: SunFire.(TM). Prep C 18
With
thionyl chloride; hydroxylamine hydrochloride; sodium acetate; triethylamine;
N,N-dimethyl-formamide;
In
methanol; dichloromethane; isopropyl alcohol;
