N-[4-(chloromethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide

Base Information

Chemical Name:N-[4-(chloromethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide
CAS No.:229006-62-6
Molecular Formula:C₂₄H₂₀ClNO
Molecular Weight:373.882
Hs Code.:

Synonyms:N-[4-(chloromethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide

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Chemical Property of N-[4-(chloromethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide

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Technology Process of N-[4-(chloromethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide

There total 14 articles about N-[4-(chloromethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 229006-57-9
N-[4-(hydroxymethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide

: 229006-62-6
N-[4-(chloromethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide

Guidance literature:: With pyridine; thionyl chloride; In chloroform; at 20 ℃; for 17h;
DOI:10.1021/jm9906264

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 229006-57-9
N-[4-(hydroxymethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide

: 229006-62-6
N-[4-(chloromethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide

Guidance literature:: With hydrogenchloride; triethylamine; lithium chloride; In dichloromethane;

Reference yield:

: 619-73-8
4-nitrobenzyl chloride

: 229006-62-6
N-[4-(chloromethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / imidazole / dimethylformamide / 1.5 h / 20 °C

2: 94 percent / H₂ / 10percent Pd/C / ethyl acetate / 2 h / 20 °C

3: Et₃N / tetrahydrofuran / 0.5 h / 20 °C

4: 91 percent / 6 N aq. HCl / acetone / 0.75 h / 20 °C

5: 83 percent / thionyl chloride; pyridine / CHCl₃ / 17 h / 20 °C

With pyridine; 1H-imidazole; hydrogenchloride; thionyl chloride; hydrogen; triethylamine; 10percent Pd/C; In tetrahydrofuran; chloroform; ethyl acetate; N,N-dimethyl-formamide; acetone; 1: silylation / 2: Catalytic hydrogenation / 3: Acylation / 4: acidolysis / 5: Chlorination;
DOI:10.1021/jm9906264