N-[4-(hydroxymethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide

Base Information

Chemical Name:N-[4-(hydroxymethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide
CAS No.:229006-57-9
Molecular Formula:C₂₄H₂₁NO₂
Molecular Weight:355.436
Hs Code.:

Synonyms:N-[4-(hydroxymethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide

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Chemical Property of N-[4-(hydroxymethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide

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Technology Process of N-[4-(hydroxymethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide

There total 12 articles about N-[4-(hydroxymethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 7-phenyl-3,4-dihydro-naphthalene-2-carboxylic acid [4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-amide

: 229006-57-9
N-[4-(hydroxymethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide

Guidance literature:: With hydrogenchloride; In acetone; at 20 ℃; for 0.75h;
DOI:10.1021/jm9906264

Reference yield:

: 619-73-8
4-nitrobenzyl chloride

: 229006-57-9
N-[4-(hydroxymethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / imidazole / dimethylformamide / 1.5 h / 20 °C

2: 94 percent / H₂ / 10percent Pd/C / ethyl acetate / 2 h / 20 °C

3: Et₃N / tetrahydrofuran / 0.5 h / 20 °C

4: 91 percent / 6 N aq. HCl / acetone / 0.75 h / 20 °C

With 1H-imidazole; hydrogenchloride; hydrogen; triethylamine; 10percent Pd/C; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; acetone; 1: silylation / 2: Catalytic hydrogenation / 3: Acylation / 4: acidolysis;
DOI:10.1021/jm9906264

Reference yield:

: 135605-97-9
tert-butyldimethyl-4-nitrobenzyloxysilane

: 229006-57-9
N-[4-(hydroxymethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / H₂ / 10percent Pd/C / ethyl acetate / 2 h / 20 °C

2: Et₃N / tetrahydrofuran / 0.5 h / 20 °C

3: 91 percent / 6 N aq. HCl / acetone / 0.75 h / 20 °C

With hydrogenchloride; hydrogen; triethylamine; 10percent Pd/C; In tetrahydrofuran; ethyl acetate; acetone; 1: Catalytic hydrogenation / 2: Acylation / 3: acidolysis;
DOI:10.1021/jm9906264