4-benzyloxy-3-methoxy-2-(3,4,5-trimethoxyphenylamino)benzoic acid

Base Information

• Chemical Name: 4-benzyloxy-3-methoxy-2-(3,4,5-trimethoxyphenylamino)benzoic acid
• CAS No.: 1325207-40-6
• Molecular Formula: C₂₄H₂₅NO₇
• Molecular Weight: 439.465
• Mol file: 1325207-40-6.mol

Synonyms:4-benzyloxy-3-methoxy-2-(3,4,5-trimethoxyphenylamino)benzoic acid

Chemical Property of 4-benzyloxy-3-methoxy-2-(3,4,5-trimethoxyphenylamino)benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-benzyloxy-3-methoxy-2-(3,4,5-trimethoxyphenylamino)benzoic acid

There total 2 articles about 4-benzyloxy-3-methoxy-2-(3,4,5-trimethoxyphenylamino)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

4-benzyloxy-2-iodo-3-methoxybenzoic acid (1325207-38-2) + 3,4,5-Trimethoxyaniline (24313-88-0) → 4-benzyloxy-3-methoxy-2-(3,4,5-trimethoxyphenylamino)benzoic acid (1325207-40-6)

Guidance literature:

With copper(l) iodide; copper; potassium carbonate; In N,N-dimethyl-formamide; at 40 - 50 ℃;

DOI:10.1016/j.tet.2011.06.062

Reference yield:

2-amino-3-methoxy-4-benzyloxybenzoic acid (23938-73-0) → 4-benzyloxy-3-methoxy-2-(3,4,5-trimethoxyphenylamino)benzoic acid (1325207-40-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water; acetone / 3 h / 7 - 10 °C / Cooling with ice

1.2: 7 - 90 °C

2.1: copper(l) iodide; copper; potassium carbonate / N,N-dimethyl-formamide / 40 - 50 °C

With hydrogenchloride; copper(l) iodide; copper; potassium carbonate; sodium nitrite; In water; N,N-dimethyl-formamide; acetone; 2.1: Ullmann condensation;

DOI:10.1016/j.tet.2011.06.062

Reference yield:

4-benzyloxy-3-methoxy-2-(3,4,5-trimethoxyphenylamino)benzoic acid (1325207-40-6) → C24H24ClNO6

Guidance literature:

With N,N-dimethyl-formamide; trichlorophosphate; at 60 ℃; for 1h;

DOI:10.1016/j.tet.2011.06.062

upstream raw materials:

4-benzyloxy-2-iodo-3-methoxybenzoic acid

3,4,5-Trimethoxyaniline

2-amino-3-methoxy-4-benzyloxybenzoic acid

Downstream raw materials:

6-benzyloxy-1,2,3,5-tetramethoxy-10H-acridin-9-one

(E)-3-(6-benzyloxy-1,2,3,5-tetramethoxy-9-oxo-9H-acridin-10-yl)acrylic acid

(E)-3-(6-benzyloxy-1,2,3,5-tetramethoxy-9-oxo-9H-acridin-10-yl)acrylic acid