2-[(1R,2R)-2-(dimethylamino)cyclohexylamino]-7-(trifluoromethyl)quinazolin-4(3H)-one

Base Information

Chemical Name:2-[(1R,2R)-2-(dimethylamino)cyclohexylamino]-7-(trifluoromethyl)quinazolin-4(3H)-one
CAS No.:1379685-86-5
Molecular Formula:C₁₇H₂₁F₃N₄O
Molecular Weight:354.375
Hs Code.:

Synonyms:2-[(1R,2R)-2-(dimethylamino)cyclohexylamino]-7-(trifluoromethyl)quinazolin-4(3H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[(1R,2R)-2-(dimethylamino)cyclohexylamino]-7-(trifluoromethyl)quinazolin-4(3H)-one

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Technology Process of 2-[(1R,2R)-2-(dimethylamino)cyclohexylamino]-7-(trifluoromethyl)quinazolin-4(3H)-one

There total 8 articles about 2-[(1R,2R)-2-(dimethylamino)cyclohexylamino]-7-(trifluoromethyl)quinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 320778-92-5
(1R,2R)-N,N-dimethylcyclohexane-1,2-diamine

: 159870-93-6
2-chloro-7-(trifluoromethyl)quinazolin-4(3H)-one

: 1379685-86-5
2-[(1R,2R)-2-(dimethylamino)cyclohexylamino]-7-(trifluoromethyl)quinazolin-4(3H)-one

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethanol; for 12h; Reflux; Inert atmosphere;
DOI:10.1002/ejoc.201200118

Reference yield:

: 877677-96-8
N-[(1R,2R)-2-(dimethylamino)cyclohexyl]benzamide

: 1379685-86-5
2-[(1R,2R)-2-(dimethylamino)cyclohexylamino]-7-(trifluoromethyl)quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water / Reflux; Inert atmosphere

2: sodium hydroxide / dichloromethane / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane; ethanol / 12 h / Reflux; Inert atmosphere

With hydrogenchloride; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water;
DOI:10.1002/ejoc.201200118

Reference yield:

: 778-94-9
2-nitro-4-trifluoromethyl-benzonitrile

: 1379685-86-5
2-[(1R,2R)-2-(dimethylamino)cyclohexylamino]-7-(trifluoromethyl)quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogen bromide / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C / 3800.26 Torr

3: 4 h / 160 - 180 °C / Inert atmosphere

4: phosphorus pentachloride; trichlorophosphate / 4 h / Reflux; Inert atmosphere

5: sodium hydroxide / tetrahydrofuran / 20 °C / Inert atmosphere

6: hydrogenchloride / 1,4-dioxane; ethanol / 12 h / Reflux; Inert atmosphere

With hydrogenchloride; phosphorus pentachloride; palladium 10% on activated carbon; hydrogen bromide; hydrogen; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol;
DOI:10.1002/ejoc.201200118