CYCLOPENTYL 2-METHOXYPHENYL KETONE

Base Information

• Chemical Name: CYCLOPENTYL 2-METHOXYPHENYL KETONE
• CAS No.: 7063-68-5
• Molecular Formula: C13H16O2
• Molecular Weight: 204.269
• Hs Code.: 2914509090
• Mol file: 7063-68-5.mol

Synonyms:Ketone,cyclopentyl o-methoxyphenyl (7CI,8CI);Cyclopentyl 2-methoxyphenyl ketone;cyclopentyl(2-methoxyphenyl)methanone;

Chemical Property of CYCLOPENTYL 2-METHOXYPHENYL KETONE

Chemical Property:

• Vapor Pressure: 4.72E-11mmHg at 25°C
• Refractive Index: 1.685
• Boiling Point: 313.5 °C at 760 mmHg
• Flash Point: 134.6 °C
• PSA: 26.30000
• Density: 1.076 g/cm³
• LogP: 3.06810

Purity/Quality:

99% ^*data from raw suppliers

cyclopentyl(2-methoxyphenyl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CYCLOPENTYL 2-METHOXYPHENYL KETONE

There total 2 articles about CYCLOPENTYL 2-METHOXYPHENYL KETONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxy-benzonitrile (6609-56-9) + cyclopentylmagnesium bromide (33240-34-5) → cyclopentyl(2-methoxyphenyl)methanone (7063-68-5)

Guidance literature:

2-methoxy-benzonitrile; cyclopentylmagnesium bromide; In diethyl ether; at 0 ℃; Inert atmosphere; Reflux;

With water; In diethyl ether; Acidic conditions;

DOI:10.1002/anie.200801173

Reference yield:

2-bromoanisole (578-57-4) + N-Cyclopentanecarbonyl-N,O-dimethylhydroxylamine (167303-65-3) → cyclopentyl(2-methoxyphenyl)methanone (7063-68-5)

Guidance literature:

2-bromoanisole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

N-Cyclopentanecarbonyl-N,O-dimethylhydroxylamine; In tetrahydrofuran; hexane; at -78 - 20 ℃;

DOI:10.1021/jo0352023

Reference yield:

cyclopentyl(2-methoxyphenyl)methanone (7063-68-5) → cyclopentyl-(2-hydroxy-phenyl)-methanone (51795-96-1)

Guidance literature:

With boron trichloride; In dichloromethane; at -78 - 20 ℃;

DOI:10.1021/jo0352023

upstream raw materials:

2-bromoanisole

N-Cyclopentanecarbonyl-N,O-dimethylhydroxylamine

2-methoxy-benzonitrile

cyclopentylmagnesium bromide

Downstream raw materials:

cyclopentyl-(2-hydroxy-phenyl)-methanone

2,2-spiropentanylbenzofuran-3-one

trifluoromethanesulfonic acid 2-cyclopentanecarbonylphenyl ester

Refernces

• 1、 Coe, Jotham W.,Bianco, Krista E.,Boscoe, Brian P.,Brooks, Paige R.,Cox, Eric D.,Vetelino, Michael G.. "Unexpected Migration and Oxidative Cyclization of Substituted 2-Acetophenone Triflates under Basic Conditions: Synthetic and Mechanistic Insights". . p. 9964 - 9970. Retrieved 2007/10/03.