N²-(2-bromo-4-isopropyl-phenyl)-N⁴-ethyl-N⁴-(3-methanesulfonyl-propyl)-6-methyl-3-nitro-pyridine-2,4-diamine

Base Information

• Chemical Name: N²-(2-bromo-4-isopropyl-phenyl)-N⁴-ethyl-N⁴-(3-methanesulfonyl-propyl)-6-methyl-3-nitro-pyridine-2,4-diamine
• CAS No.: 856698-76-5
• Molecular Formula: C₂₁H₂₉BrN₄O₄S
• Molecular Weight: 513.456
• Mol file: 856698-76-5.mol

Synonyms:N²-(2-bromo-4-isopropyl-phenyl)-N⁴-ethyl-N⁴-(3-methanesulfonyl-propyl)-6-methyl-3-nitro-pyridine-2,4-diamine

Chemical Property of N²-(2-bromo-4-isopropyl-phenyl)-N⁴-ethyl-N⁴-(3-methanesulfonyl-propyl)-6-methyl-3-nitro-pyridine-2,4-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-(2-bromo-4-isopropyl-phenyl)-N⁴-ethyl-N⁴-(3-methanesulfonyl-propyl)-6-methyl-3-nitro-pyridine-2,4-diamine

There total 4 articles about N²-(2-bromo-4-isopropyl-phenyl)-N⁴-ethyl-N⁴-(3-methanesulfonyl-propyl)-6-methyl-3-nitro-pyridine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxy-6-methyl-3-nitro-2(1H)-pyridinone (4966-90-9) → N2-(2-bromo-4-isopropyl-phenyl)-N4-ethyl-N4-(3-methanesulfonyl-propyl)-6-methyl-3-nitro-pyridine-2,4-diamine (856698-76-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: cyclohexylamine / methanol / 0.67 h / 20 °C

1.2: POCl₃ / 80 h / 20 °C

2.1: DIEA / acetonitrile / Heating

3.1: POCl₃ / Heating

4.1: 130 °C

With cyclohexylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; acetonitrile;

DOI:10.1021/jm049737f

Reference yield:

4-chloro-6-methyl-3-nitro-2-pyridone (95835-64-6) → N2-(2-bromo-4-isopropyl-phenyl)-N4-ethyl-N4-(3-methanesulfonyl-propyl)-6-methyl-3-nitro-pyridine-2,4-diamine (856698-76-5)

Guidance literature:

Multi-step reaction with 3 steps

1: DIEA / acetonitrile / Heating

2: POCl₃ / Heating

3: 130 °C

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In acetonitrile;

DOI:10.1021/jm049737f

Reference yield:

4-[ethyl-(3-methanesulfonyl-propyl)-amino]-6-methyl-3-nitro-1H-pyridin-2-one → N2-(2-bromo-4-isopropyl-phenyl)-N4-ethyl-N4-(3-methanesulfonyl-propyl)-6-methyl-3-nitro-pyridine-2,4-diamine (856698-76-5)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃ / Heating

2: 130 °C

With trichlorophosphate;

DOI:10.1021/jm049737f

upstream raw materials:

2-bromo-4-isopropylaniline

(2-chloro-6-methyl-3-nitro-pyridin-4-yl)-ethyl-(3-methanesulfonyl-propyl)-amine

4-hydroxy-6-methyl-3-nitro-2(1H)-pyridinone

4-chloro-6-methyl-3-nitro-2-pyridone

Downstream raw materials:

((2-bromo-4-isopropyl-phenyl)-{4-[ethyl-(3-methanesulfonyl-propyl)-amino]-6-methyl-3-nitro-pyridin-2-yl}-amino)-acetic acid ethyl ester