diisopropyl (2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate

Base Information

• Chemical Name: diisopropyl (2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate
• CAS No.: 1184912-66-0
• Molecular Formula: C₂₂H₃₀NO₄P
• Molecular Weight: 403.458
• Mol file: 1184912-66-0.mol

Synonyms:diisopropyl (2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate

Chemical Property of diisopropyl (2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diisopropyl (2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate

There total 4 articles about diisopropyl (2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline (78317-83-6) + diisopropyl hydrogenphosphonate (1809-20-7) → diisopropyl (2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate (1184912-66-0)

Guidance literature:

With oxygen; molybdenum(VI) oxide; In methanol; at 60 ℃; for 24h; under 760.051 Torr;

DOI:10.1016/j.tetlet.2012.01.031

Reference yield:

1,2,3,4-tetrahydroisoquinoline (91-21-4) → diisopropyl (2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate (1184912-66-0)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; potassium phosphate / ethylene glycol; isopropyl alcohol / 24 h / 90 °C / Inert atmosphere

2: oxygen; molybdenum(VI) oxide / methanol / 24 h / 60 °C / 760.05 Torr

With potassium phosphate; copper(l) iodide; oxygen; molybdenum(VI) oxide; In methanol; ethylene glycol; isopropyl alcohol;

DOI:10.1016/j.tetlet.2012.01.031

Reference yield:

benzaldehyde (100-52-7) → diisopropyl (2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)phosphonate (1184912-66-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: ammonium acetate; acetic acid / 1.5 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / Reflux

3.1: formic acid / 0.17 h / 0 °C

3.2: 24 h / 50 °C

4.1: copper(l) iodide; potassium phosphate / ethylene glycol; isopropyl alcohol / 24 h / 90 °C / Inert atmosphere

5.1: oxygen; molybdenum(VI) oxide / methanol / 24 h / 60 °C / 760.05 Torr

With potassium phosphate; copper(l) iodide; lithium aluminium tetrahydride; formic acid; ammonium acetate; oxygen; acetic acid; molybdenum(VI) oxide; In tetrahydrofuran; methanol; ethylene glycol; isopropyl alcohol;

DOI:10.1016/j.tetlet.2012.01.031

upstream raw materials:

2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

diisopropyl hydrogenphosphonate

1,2,3,4-tetrahydroisoquinoline

(2-nitroethenyl)benzene