(R)-2-[(1S,3S,4R)-4-Methyl-2-oxo-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester

Base Information

• Chemical Name: (R)-2-[(1S,3S,4R)-4-Methyl-2-oxo-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester
• CAS No.: 103740-01-8
• Molecular Formula: C₁₅H₂₄O₄
• Molecular Weight: 268.353
• Mol file: 103740-01-8.mol

Synonyms:(R)-2-[(1S,3S,4R)-4-Methyl-2-oxo-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester

Chemical Property of (R)-2-[(1S,3S,4R)-4-Methyl-2-oxo-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-[(1S,3S,4R)-4-Methyl-2-oxo-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester

There total 9 articles about (R)-2-[(1S,3S,4R)-4-Methyl-2-oxo-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(R)-methyl 2-((3R,6R,9aR)-9a-formyl-3-methoxy-3,6-dimethyloctahydro-3H-benzo[c][1,2]dioxepin-9-yl)propanoate (95851-75-5) → (R)-2-[(1S,3S,4R)-4-Methyl-2-oxo-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester (103740-01-8)

Guidance literature:

With potassium permanganate; sodium dihydrogenphosphate; In water; tert-butyl alcohol; at 20 ℃; for 20h;

DOI:10.1002/chem.201300076

Reference yield: 90.0%

methanol (67-56-1) + C12H13O2(CH3)3(O)(OO) (63968-64-9) → (R)-2-((1R,4S,4aR,7R,9aS)-4a-Formyl-7-hydroxy-1,7-dimethyl-octahydro-5,6-dioxa-benzocyclohepten-4-yl)-propionic acid methyl ester (95851-77-7) + (R)-2-[(1S,3S,4R)-4-Methyl-2-oxo-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester (103740-01-8)

Guidance literature:

With sulfuric acid; for 0.166667h;

DOI:10.1016/S0040-4020(01)00711-6

Reference yield: 75.0%

C12H13O2(CH3)3(O)(OO) (63968-64-9) → (R)-2-[(1S,3S,4R)-4-Methyl-2-oxo-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester (103740-01-8)

Guidance literature:

With sulfuric acid; In methanol;

DOI:10.1016/S0040-4020(01)00633-0

upstream raw materials:

(R)-2-((1R,4S,4aR,7R,9aS)-4a-Formyl-7-hydroxy-1,7-dimethyl-octahydro-5,6-dioxa-benzocyclohepten-4-yl)-propionic acid methyl ester

C₁₂H₁₃O₂(CH₃)3(O)(OO)

methanol

(R)-methyl 2-((3R,6R,9aR)-9a-formyl-3-methoxy-3,6-dimethyloctahydro-3H-benzo[c][1,2]dioxepin-9-yl)propanoate

Downstream raw materials:

C₁₂H₁₃O₂(CH₃)3(O)(OO)

C₂₄H₃₄O₇S

C₁₇H₃₂O₆

(+)-deoxyartemisinin