2,4-DIMETHYL-6-METHOXYPHENYLBORONIC ACID

Base Information

• Chemical Name: 2,4-DIMETHYL-6-METHOXYPHENYLBORONIC ACID
• CAS No.: 355836-08-7
• Molecular Formula: C9H13 B O3
• Molecular Weight: 180.011
• Hs Code.: 2931900090
• Mol file: 355836-08-7.mol

Synonyms:Boronicacid, (2-methoxy-4,6-dimethylphenyl)- (9CI);2,4-Dimethyl-6-methoxyphenylboronic acid; 2-Methoxy-4,6-dimethylbenzeneboronicacid; 4,6-Dimethyl-2-methoxybenzeneboronic acid

Chemical Property of 2,4-DIMETHYL-6-METHOXYPHENYLBORONIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.517
• Boiling Point: 349.832°C at 760 mmHg
• PKA: 8.94±0.58(Predicted)
• Flash Point: 165.373°C
• PSA: 49.69000
• Density: 1.114g/cm³
• LogP: -0.00820
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2,4-Dimethyl-6-methoxyphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-DIMETHYL-6-METHOXYPHENYLBORONIC ACID

There total 3 articles about 2,4-DIMETHYL-6-METHOXYPHENYLBORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

Trimethyl borate (121-43-7,63156-11-6) + 3,5-dimethylmethoxybenzene (874-63-5) → 2-methoxy-4,6-dimethylbenzeneboronic acid (355836-08-7)

Guidance literature:

3,5-dimethylmethoxybenzene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; hexane; at 0 ℃; for 5h;

Trimethyl borate; In diethyl ether; hexane; at -78 ℃; for 18h;

Reference yield:

3,5-dimethylmethoxybenzene (874-63-5) → 2-methoxy-4,6-dimethylbenzeneboronic acid (355836-08-7)

Guidance literature:

3,5-dimethylmethoxybenzene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; hexane; at 0 - 20 ℃; for 1h;

With Trimethyl borate; In diethyl ether; hexane; at -78 - 20 ℃;

With hydrogenchloride; water; In diethyl ether; hexane; pH=1;

Reference yield:

C11H17BO3 → 2-methoxy-4,6-dimethylbenzeneboronic acid (355836-08-7)

Guidance literature:

With hydrogenchloride; In water;

DOI:10.1016/j.bmcl.2008.07.063

upstream raw materials:

Trimethyl borate

3,5-dimethylmethoxybenzene

Downstream raw materials:

C₁₅H₁₈N₂O

C₂₀H₂₈N₂O₃

C₂₀H₂₉N₃O

2’-methoxy-4’,6’-dimethylisoflavanone