(2-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}-2,3-dihydro-1H-isoindol-5-yl)acetaldehyde

Base Information

Chemical Name:(2-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}-2,3-dihydro-1H-isoindol-5-yl)acetaldehyde
CAS No.:1351815-47-8
Molecular Formula:C₃₄H₃₁NO₄
Molecular Weight:517.624
Hs Code.:

Synonyms:(2-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}-2,3-dihydro-1H-isoindol-5-yl)acetaldehyde

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Chemical Property of (2-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}-2,3-dihydro-1H-isoindol-5-yl)acetaldehyde

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Technology Process of (2-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}-2,3-dihydro-1H-isoindol-5-yl)acetaldehyde

There total 9 articles about (2-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}-2,3-dihydro-1H-isoindol-5-yl)acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 912545-08-5
2,4-bis-benzyloxy-5-isopropenyl-benzoic acid methyl ester

: 1351815-47-8
(2-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}-2,3-dihydro-1H-isoindol-5-yl)acetaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide; methanol / 20 h / 75 °C

1.2: 0.5 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 100 h / 20 °C

3.1: Wilkinson's catalyst / ethyl acetate / 24 h / 20 °C

4.1: Dess-Martin periodane / dichloromethane / 1.5 h

With methanol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; dmap; Wilkinson's catalyst; In dichloromethane; ethyl acetate;

Reference yield:

: 1351815-46-7
[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl][5-(2-hydroxyethyl)-1,3-dihydro-2H-isoindol-2-yl]methanone

: 1351815-47-8
(2-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}-2,3-dihydro-1H-isoindol-5-yl)acetaldehyde

Guidance literature:: With Dess-Martin periodane; In dichloromethane; for 1.5h;

Reference yield:

: 100-39-0
benzyl bromide

: 1351815-47-8
(2-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}-2,3-dihydro-1H-isoindol-5-yl)acetaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / acetonitrile / 42 h / 75 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h

2.2: 0.5 h

3.1: potassium hydroxide; methanol / 20 h / 75 °C

3.2: 0.5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 100 h / 20 °C

5.1: Wilkinson's catalyst / ethyl acetate / 24 h / 20 °C

6.1: Dess-Martin periodane / dichloromethane / 1.5 h

With methanol; potassium tert-butylate; potassium carbonate; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; dmap; Wilkinson's catalyst; In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile;