[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl][5-(2-hydroxyethyl)-1,3-dihydro-2H-isoindol-2-yl]methanone

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Chemical Name:[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl][5-(2-hydroxyethyl)-1,3-dihydro-2H-isoindol-2-yl]methanone
CAS No.:1351815-46-7
Molecular Formula:C₃₄H₃₃NO₄
Molecular Weight:519.64
Hs Code.:

Synonyms:[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl][5-(2-hydroxyethyl)-1,3-dihydro-2H-isoindol-2-yl]methanone

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Chemical Property of [2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl][5-(2-hydroxyethyl)-1,3-dihydro-2H-isoindol-2-yl]methanone

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Technology Process of [2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl][5-(2-hydroxyethyl)-1,3-dihydro-2H-isoindol-2-yl]methanone

There total 8 articles about [2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl][5-(2-hydroxyethyl)-1,3-dihydro-2H-isoindol-2-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1019890-32-4
2,4-Bis(benzyloxy)-5-isopropenyl-N,N-dipropargylbenzamide

: 927-74-2
3-Butyn-1-ol

: 1351815-46-7
[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl][5-(2-hydroxyethyl)-1,3-dihydro-2H-isoindol-2-yl]methanone

Guidance literature:: Wilkinson's catalyst; In ethyl acetate; at 20 ℃; for 24h;

Reference yield:

: 912545-08-5
2,4-bis-benzyloxy-5-isopropenyl-benzoic acid methyl ester

: 1351815-46-7
[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl][5-(2-hydroxyethyl)-1,3-dihydro-2H-isoindol-2-yl]methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide; methanol / 20 h / 75 °C

1.2: 0.5 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 100 h / 20 °C

3.1: Wilkinson's catalyst / ethyl acetate / 24 h / 20 °C

With methanol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; dmap; Wilkinson's catalyst; In dichloromethane; ethyl acetate;

Reference yield:

: 100-39-0
benzyl bromide

: 1351815-46-7
[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl][5-(2-hydroxyethyl)-1,3-dihydro-2H-isoindol-2-yl]methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetonitrile / 42 h / 75 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h

2.2: 0.5 h

3.1: potassium hydroxide; methanol / 20 h / 75 °C

3.2: 0.5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 100 h / 20 °C

5.1: Wilkinson's catalyst / ethyl acetate / 24 h / 20 °C

With methanol; potassium tert-butylate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; dmap; Wilkinson's catalyst; In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile;