(2-benzyloxycarbonylaminoethyl)phosphonic acid dibenzyl ester

Base Information

• Chemical Name: (2-benzyloxycarbonylaminoethyl)phosphonic acid dibenzyl ester
• CAS No.: 299422-83-6
• Molecular Formula: C₂₄H₂₆NO₅P
• Molecular Weight: 439.448
• Mol file: 299422-83-6.mol

Synonyms:(2-benzyloxycarbonylaminoethyl)phosphonic acid dibenzyl ester

Chemical Property of (2-benzyloxycarbonylaminoethyl)phosphonic acid dibenzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (2-benzyloxycarbonylaminoethyl)phosphonic acid dibenzyl ester

There total 4 articles about (2-benzyloxycarbonylaminoethyl)phosphonic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-(((benzyloxy)carbonyl)amino)ethyl 4-methylbenzenesulfonate (93407-96-6) + sodium dibenzyl phosphinate → (2-benzyloxycarbonylaminoethyl)phosphonic acid dibenzyl ester (299422-83-6)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

DOI:10.1016/S0960-894X(00)00328-0

Reference yield: 62.0%

Dibenzyl phosphite (17176-77-1) + 2-(((benzyloxy)carbonyl)amino)ethyl 4-methylbenzenesulfonate (93407-96-6) → (2-benzyloxycarbonylaminoethyl)phosphonic acid dibenzyl ester (299422-83-6)

Guidance literature:

Dibenzyl phosphite; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃;

2-(((benzyloxy)carbonyl)amino)ethyl 4-methylbenzenesulfonate; In N,N-dimethyl-formamide; at 65 ℃; for 2h;

DOI:10.1021/jo0508595

Reference yield:

benzyl 2-hydroxyethylcarbamate (77987-49-6) → (2-benzyloxycarbonylaminoethyl)phosphonic acid dibenzyl ester (299422-83-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / pyridine

2: 78 percent / tetrahydrofuran / 20 °C

With pyridine; In tetrahydrofuran; 1: Tosylation / 2: Substitution;

DOI:10.1016/S0960-894X(00)00328-0

upstream raw materials:

2-(((benzyloxy)carbonyl)amino)ethyl 4-methylbenzenesulfonate

Dibenzyl phosphite

benzyl 2-hydroxyethylcarbamate

benzyl chloroformate

Downstream raw materials:

C₁₇H₁₉ClNO₄P