3-Phenyllevulinic Acid Dimethylamide

Base Information

• Chemical Name: 3-Phenyllevulinic Acid Dimethylamide
• CAS No.: 57734-28-8
• Molecular Formula: C₁₃H₁₇NO₂
• Molecular Weight: 219.283
• Mol file: 57734-28-8.mol

Synonyms:3-Phenyllevulinic Acid Dimethylamide

Chemical Property of 3-Phenyllevulinic Acid Dimethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Phenyllevulinic Acid Dimethylamide

There total 1 articles about 3-Phenyllevulinic Acid Dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-phenyl-acetone (103-79-7,136675-26-8) + 2-chloro-N,N-dimethylacetamide (2675-89-0) → 3-Phenyllevulinic Acid Dimethylamide (57734-28-8)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide;

DOI:10.1055/s-1975-23814

Reference yield: 73.0%

3-Phenyllevulinic Acid Dimethylamide (57734-28-8) + acrylonitrile (107-13-1,25014-41-9) → 3-Acetyl-5-cyano-3-phenyl-pentanoic acid dimethylamide (74528-36-2)

Guidance literature:

With methanol; tetramethyl ammoniumhydroxide; In tert-butyl alcohol; at 50 ℃; for 2h;

DOI:10.1055/s-1980-29034

Reference yield:

3-Phenyllevulinic Acid Dimethylamide (57734-28-8) → 3a-Phenyl-3,3a,4,5-tetrahydro-benzofuran-2,6-dione (74528-54-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 73 percent / tetramethylammonium hydroxide / MeOH / 2-methyl-propan-2-ol / 2 h / 50 °C

2: 79 percent / 12percent NaOH / 12 h / Heating

3: 73 percent / H₂SO₄ / 5 h / Heating

4: 73 percent / Na, EtOH / toluene / 3 h / Heating

5: 85 percent / hydroysis

6: 49 percent / Ac₂O / 2 h / Heating; other cyclization agents

With methanol; sodium hydroxide; ethanol; sulfuric acid; tetramethyl ammoniumhydroxide; sodium; acetic anhydride; In toluene; tert-butyl alcohol;

DOI:10.1055/s-1980-29034

upstream raw materials:

1-phenyl-acetone

2-chloro-N,N-dimethylacetamide

Downstream raw materials:

3-Acetyl-5-cyano-3-phenyl-pentanoic acid dimethylamide

4-Oxo-3-phenylpentanoic acid

3a-Phenyl-3,3a,4,5-tetrahydro-benzofuran-2,6-dione

(2,4-Dioxo-1-phenyl-cyclohexyl)-acetic acid