(E)-(1S,2R)-1-(2-Methoxymethoxy-ethyl)-2-methyl-4-phenyl-but-3-enylamine

Base Information

• Chemical Name: (E)-(1S,2R)-1-(2-Methoxymethoxy-ethyl)-2-methyl-4-phenyl-but-3-enylamine
• CAS No.: 326473-57-8
• Molecular Formula: C₁₅H₂₃NO₂
• Molecular Weight: 249.353
• Mol file: 326473-57-8.mol

Synonyms:(E)-(1S,2R)-1-(2-Methoxymethoxy-ethyl)-2-methyl-4-phenyl-but-3-enylamine

Chemical Property of (E)-(1S,2R)-1-(2-Methoxymethoxy-ethyl)-2-methyl-4-phenyl-but-3-enylamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (E)-(1S,2R)-1-(2-Methoxymethoxy-ethyl)-2-methyl-4-phenyl-but-3-enylamine

There total 1 articles about (E)-(1S,2R)-1-(2-Methoxymethoxy-ethyl)-2-methyl-4-phenyl-but-3-enylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((E)-(3R,4S)-4-Azido-6-methoxymethoxy-3-methyl-hex-1-enyl)-benzene → (E)-(1S,2R)-1-(2-Methoxymethoxy-ethyl)-2-methyl-4-phenyl-but-3-enylamine (326473-57-8)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 1h;

DOI:10.1016/S0040-4020(00)00766-3

Reference yield: 82.0%

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) + (E)-(1S,2R)-1-(2-Methoxymethoxy-ethyl)-2-methyl-4-phenyl-but-3-enylamine (326473-57-8) → {(S)-1-[(E)-(1S,2R)-1-(2-Methoxymethoxy-ethyl)-2-methyl-4-phenyl-but-3-enylcarbamoyl]-3-methyl-butyl}-carbamic acid tert-butyl ester (402731-95-7)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1016/S0040-4020(00)00766-3

Reference yield: 78.0%

(E)-(1S,2R)-1-(2-Methoxymethoxy-ethyl)-2-methyl-4-phenyl-but-3-enylamine (326473-57-8) + (2S)-2-[(3'-{[(tert-butoxy)carbonyl]amino}propionyl)oxy]-4-methylpentanoic acid (326473-59-0) → 3-tert-Butoxycarbonylamino-propionic acid (S)-1-[(E)-(1S,2R)-1-(2-methoxymethoxy-ethyl)-2-methyl-4-phenyl-but-3-enylcarbamoyl]-3-methyl-butyl ester (402731-46-8)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/S0040-4020(00)00766-3

Downstream raw materials:

{(S)-1-[(E)-(1S,2R)-1-(2-Methoxymethoxy-ethyl)-2-methyl-4-phenyl-but-3-enylcarbamoyl]-3-methyl-butyl}-carbamic acid tert-butyl ester

3-tert-Butoxycarbonylamino-propionic acid (S)-1-[(E)-(1S,2R)-1-(2-methoxymethoxy-ethyl)-2-methyl-4-phenyl-but-3-enylcarbamoyl]-3-methyl-butyl ester

3-tert-Butoxycarbonylamino-propionic acid (S)-1-[(E)-(1S,2R)-1-(2-hydroxy-ethyl)-2-methyl-4-phenyl-but-3-enylcarbamoyl]-3-methyl-butyl ester

(2-{(S)-1-[(E)-(1S,2R)-1-(2-Hydroxy-ethyl)-2-methyl-4-phenyl-but-3-enylcarbamoyl]-3-methyl-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester