(2-{(S)-1-[(E)-(1S,2R)-1-(2-Hydroxy-ethyl)-2-methyl-4-phenyl-but-3-enylcarbamoyl]-3-methyl-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester

Base Information

• Chemical Name: (2-{(S)-1-[(E)-(1S,2R)-1-(2-Hydroxy-ethyl)-2-methyl-4-phenyl-but-3-enylcarbamoyl]-3-methyl-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester
• CAS No.: 326473-66-9
• Molecular Formula: C₂₇H₄₃N₃O₅
• Molecular Weight: 489.656
• Mol file: 326473-66-9.mol

Synonyms:(2-{(S)-1-[(E)-(1S,2R)-1-(2-Hydroxy-ethyl)-2-methyl-4-phenyl-but-3-enylcarbamoyl]-3-methyl-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester

Chemical Property of (2-{(S)-1-[(E)-(1S,2R)-1-(2-Hydroxy-ethyl)-2-methyl-4-phenyl-but-3-enylcarbamoyl]-3-methyl-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-{(S)-1-[(E)-(1S,2R)-1-(2-Hydroxy-ethyl)-2-methyl-4-phenyl-but-3-enylcarbamoyl]-3-methyl-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester

There total 4 articles about (2-{(S)-1-[(E)-(1S,2R)-1-(2-Hydroxy-ethyl)-2-methyl-4-phenyl-but-3-enylcarbamoyl]-3-methyl-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3-(tert-butyloxycarbonylamino)propionic acid (3303-84-2) + {(S)-1-[(E)-(1S,2R)-1-(2-Methoxymethoxy-ethyl)-2-methyl-4-phenyl-but-3-enylcarbamoyl]-3-methyl-butyl}-carbamic acid tert-butyl ester (402731-95-7) → (2-{(S)-1-[(E)-(1S,2R)-1-(2-Hydroxy-ethyl)-2-methyl-4-phenyl-but-3-enylcarbamoyl]-3-methyl-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester (326473-66-9)

Guidance literature:

{(S)-1-[(E)-(1S,2R)-1-(2-Methoxymethoxy-ethyl)-2-methyl-4-phenyl-but-3-enylcarbamoyl]-3-methyl-butyl}-carbamic acid tert-butyl ester; With hydrogenchloride; In methanol; for 2h;

3-(tert-butyloxycarbonylamino)propionic acid; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1016/S0040-4020(00)00766-3

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → (2-{(S)-1-[(E)-(1S,2R)-1-(2-Hydroxy-ethyl)-2-methyl-4-phenyl-but-3-enylcarbamoyl]-3-methyl-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester (326473-66-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 82 percent / DCC; DMAP / CH₂Cl₂ / 2 h / 0 °C

2.1: 10 percent HCl / methanol / 2 h

2.2: 77 percent / EDCI*HCl; DMAP / CH₂Cl₂ / 2 h / 0 °C

With hydrogenchloride; dmap; dicyclohexyl-carbodiimide; In methanol; dichloromethane; 1.1: Condensation / 2.1: Hydrolysis / 2.2: Condensation;

DOI:10.1016/S0040-4020(00)00766-3

Reference yield:

(E)-(1S,2R)-1-(2-Methoxymethoxy-ethyl)-2-methyl-4-phenyl-but-3-enylamine (326473-57-8) → (2-{(S)-1-[(E)-(1S,2R)-1-(2-Hydroxy-ethyl)-2-methyl-4-phenyl-but-3-enylcarbamoyl]-3-methyl-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester (326473-66-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 82 percent / DCC; DMAP / CH₂Cl₂ / 2 h / 0 °C

2.1: 10 percent HCl / methanol / 2 h

2.2: 77 percent / EDCI*HCl; DMAP / CH₂Cl₂ / 2 h / 0 °C

With hydrogenchloride; dmap; dicyclohexyl-carbodiimide; In methanol; dichloromethane; 1.1: Condensation / 2.1: Hydrolysis / 2.2: Condensation;

DOI:10.1016/S0040-4020(00)00766-3

upstream raw materials:

3-(tert-butyloxycarbonylamino)propionic acid

{(S)-1-[(E)-(1S,2R)-1-(2-Methoxymethoxy-ethyl)-2-methyl-4-phenyl-but-3-enylcarbamoyl]-3-methyl-butyl}-carbamic acid tert-butyl ester

N-tert-butoxycarbonyl-L-leucine

(E)-(1S,2R)-1-(2-Methoxymethoxy-ethyl)-2-methyl-4-phenyl-but-3-enylamine

Downstream raw materials:

(R)-2-{(2E,7E)-(5S,6R)-5-[(S)-2-(3-tert-Butoxycarbonylamino-propionylamino)-4-methyl-pentanoylamino]-6-methyl-8-phenyl-octa-2,7-dienoylamino}-3-(4-methoxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester