(S)-N-(1-cyano-1-phenylethyl)-P,P-diphenylphosphinamide

Base Information

• Chemical Name: (S)-N-(1-cyano-1-phenylethyl)-P,P-diphenylphosphinamide
• CAS No.: 540485-22-1
• Molecular Formula: C₂₁H₁₉N₂OP
• Molecular Weight: 346.368
• Mol file: 540485-22-1.mol

Synonyms:(S)-N-(1-cyano-1-phenylethyl)-P,P-diphenylphosphinamide

Chemical Property of (S)-N-(1-cyano-1-phenylethyl)-P,P-diphenylphosphinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(1-cyano-1-phenylethyl)-P,P-diphenylphosphinamide

There total 8 articles about (S)-N-(1-cyano-1-phenylethyl)-P,P-diphenylphosphinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

trimethylsilyl cyanide (7677-24-9) + N-[(1E)-1-phenylethylidene]-P,P-diphenylphosphinic amide (82944-84-1) → (S)-N-(1-cyano-1-phenylethyl)-P,P-diphenylphosphinamide (540485-22-1)

Guidance literature:

With 2.6-dimethylphenol; D-glucose-derived ligand; gadolinium(III) isopropoxide; In various solvent(s); at -40 ℃; for 2h;

DOI:10.1021/ja060841r

Reference yield: 84.0%

trimethylsilyl cyanide (7677-24-9) + P,P-diphenyl-N-(1-phenylethylidene)phosphinic amide (82572-06-3) → (S)-N-(1-cyano-1-phenylethyl)-P,P-diphenylphosphinamide (540485-22-1)

Guidance literature:

With gadolinium(III) isopropoxide; 2S,3S,4R-2-[CH₂P(O)Ph₂]-3-OH-4-[1-O-4,5-F₂-catechol]-THP; In various solvent(s); at -40 ℃; for 24h;

DOI:10.1021/ja034980+

Reference yield:

trimethylsilyl cyanide (7677-24-9) + P,P-diphenyl-N-(1-phenylethylidene)phosphinic amide (82572-06-3) → (S)-N-(1-cyano-1-phenylethyl)-P,P-diphenylphosphinamide (540485-22-1) + (R)-N-(1-cyano-1-phenylethyl)-P,P-diphenylphosphinamide (898288-14-7)

Guidance literature:

With chiral bis(piperidinecarboxamide) derivative; 3-chloro-benzenecarboperoxoic acid; In toluene; at -20 ℃; for 196h; Title compound not separated from byproducts;

DOI:10.1021/jo062006y

upstream raw materials:

trimethylsilyl cyanide

P,P-diphenyl-N-(1-phenylethylidene)phosphinic amide

hydrogen cyanide

N-[(1E)-1-phenylethylidene]-P,P-diphenylphosphinic amide

Downstream raw materials:

methyl (S)-2-amino-2-phenylpropanoate