N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-methoxybenzamide

Base Information

Chemical Name:N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-methoxybenzamide
CAS No.:1005786-42-4
Molecular Formula:C₂₄H₂₁N₅O₄
Molecular Weight:443.462
Hs Code.:

Synonyms:N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-methoxybenzamide

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Chemical Property of N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-methoxybenzamide

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Technology Process of N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-methoxybenzamide

There total 4 articles about N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 79-37-8
oxalyl dichloride

: 1005777-50-3
N-[6-(3-aminophenoxy)imidazo[1,2-b]pyridazine-2-yl]cyclopropanecarboxamide

: 586-38-9
3-Methoxybenzoic acid

: 1005786-42-4
N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-methoxybenzamide

Guidance literature:: With 1-methyl-pyrrolidin-2-one; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1005785-69-2
ethyl (6-iodoimidazo[1,2-b]pyridazin-2-yl)carbamate

: 1005786-42-4
N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-methoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: barium hydroxide octahydrate / 1-methyl-pyrrolidin-2-one / 12 h / 120 °C

2: N,N-dimethyl acetamide / 16 h / 4 - 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 24 h / 150 °C

4: 1-methyl-pyrrolidin-2-one / 2 h / 20 °C

With barium hydroxide octahydrate; potassium carbonate; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm300126x

Reference yield:

: 586-38-9
3-Methoxybenzoic acid

: 1005786-42-4
N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-methoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / tetrahydrofuran; N,N-dimethyl-formamide / 1.5 h / 4 - 20 °C

2: 1-methyl-pyrrolidin-2-one / 2 h / 20 °C

With oxalyl dichloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;
DOI:10.1021/jm300126x