*,R^*)>-N-<4-methyl-2-<<<1-<(4-methylphenyl)sulfonyl>-2-pyrrolidinyl>methyl>amino>pentyl>glycine

Base Information

• Chemical Name: *,R^*)>-N-<4-methyl-2-<<<1-<(4-methylphenyl)sulfonyl>-2-pyrrolidinyl>methyl>amino>pentyl>glycine
• CAS No.: 101250-10-6
• Molecular Formula: C₂₀H₃₃N₃O₄S
• Molecular Weight: 411.566

Synonyms:*,R^*)>-N-<4-methyl-2-<<<1-<(4-methylphenyl)sulfonyl>-2-pyrrolidinyl>methyl>amino>pentyl>glycine

Chemical Property of *,R^*)>-N-<4-methyl-2-<<<1-<(4-methylphenyl)sulfonyl>-2-pyrrolidinyl>methyl>amino>pentyl>glycine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of *,R^*)>-N-<4-methyl-2-<<<1-<(4-methylphenyl)sulfonyl>-2-pyrrolidinyl>methyl>amino>pentyl>glycine

There total 9 articles about *,R^*)>-N-<4-methyl-2-<<<1-<(4-methylphenyl)sulfonyl>-2-pyrrolidinyl>methyl>amino>pentyl>glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-(2-Methylpropyl)-aziridine (23852-57-5) → *,R*)>-N-<4-methyl-2-<<<1-<(4-methylphenyl)sulfonyl>-2-pyrrolidinyl>methyl>amino>pentyl>glycine (101250-10-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 90.5 percent / Et₃N / diethyl ether / 1 h / 0 °C

2: 17.6 g / ethanol / 48 h / Heating

3: H₂ / 20percent Pd/C / methanol / 2585.7 Torr

4: 2.) 5A molecular sieves, 2.) bromcresol, NaCNBH₃

5: trifluoroacetic acid (TFA)

With 5A molecular sieve; 2-bromo-6-methylphenol; hydrogen; sodium cyanoborohydride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; diethyl ether; ethanol;

DOI:10.1021/jm00156a012

Reference yield:

(S)-phenylmethyl 2-(2-methylpropyl)-1-aziridinecarboxylate (101250-56-0) → *,R*)>-N-<4-methyl-2-<<<1-<(4-methylphenyl)sulfonyl>-2-pyrrolidinyl>methyl>amino>pentyl>glycine (101250-10-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 17.6 g / ethanol / 48 h / Heating

2: H₂ / 20percent Pd/C / methanol / 2585.7 Torr

3: 2.) 5A molecular sieves, 2.) bromcresol, NaCNBH₃

4: trifluoroacetic acid (TFA)

With 5A molecular sieve; 2-bromo-6-methylphenol; hydrogen; sodium cyanoborohydride; trifluoroacetic acid; palladium on activated charcoal; In methanol; ethanol;

DOI:10.1021/jm00156a012

Reference yield:

((S)-2-Benzyloxycarbonylamino-4-methyl-pentylamino)-acetic acid tert-butyl ester (101250-58-2) → *,R*)>-N-<4-methyl-2-<<<1-<(4-methylphenyl)sulfonyl>-2-pyrrolidinyl>methyl>amino>pentyl>glycine (101250-10-6)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 20percent Pd/C / methanol / 2585.7 Torr

2: 2.) 5A molecular sieves, 2.) bromcresol, NaCNBH₃

3: trifluoroacetic acid (TFA)

With 5A molecular sieve; 2-bromo-6-methylphenol; hydrogen; sodium cyanoborohydride; trifluoroacetic acid; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00156a012

upstream raw materials:

[tert-Butoxycarbonyl-((S)-4-methyl-2-{[(S)-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethyl]-amino}-pentyl)-amino]-acetic acid tert-butyl ester

((2S)-1-p-toluenesulfonyl-2-pyrrolidinyl)methanol

(S)-2-(2-Methylpropyl)-aziridine

((S)-2-Amino-4-methyl-pentylamino)-acetic acid tert-butyl ester

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