(3'S,5'R,6'R)-1-{2'-deoxy-5'-O-[(4,4'-dimethoxytriphenyl)methyl]-6'-(trifluoroacetamido)-3',5'-ethano-β-D-ribofuranosyl}thymine 3'-(2-cyanoethyl diisopropylphosphoramidite)

Base Information

Chemical Name:(3'S,5'R,6'R)-1-{2'-deoxy-5'-O-[(4,4'-dimethoxytriphenyl)methyl]-6'-(trifluoroacetamido)-3',5'-ethano-β-D-ribofuranosyl}thymine 3'-(2-cyanoethyl diisopropylphosphoramidite)
CAS No.:258505-11-2
Molecular Formula:C₄₄H₅₁F₃N₅O₉P
Molecular Weight:881.886
Hs Code.:

(3'S,5'R,6'R)-1-{2'-deoxy-5'-O-[(4,4'-dimethoxytriphenyl)methyl]-6'-(trifluoroacetamido)-3',5'-ethano-β-D-ribofuranosyl}thymine 3'-(2-cyanoethyl diisopropylphosphoramidite)

Synonyms:(3'S,5'R,6'R)-1-{2'-deoxy-5'-O-[(4,4'-dimethoxytriphenyl)methyl]-6'-(trifluoroacetamido)-3',5'-ethano-β-D-ribofuranosyl}thymine 3'-(2-cyanoethyl diisopropylphosphoramidite)

Suppliers and Price of (3'S,5'R,6'R)-1-{2'-deoxy-5'-O-[(4,4'-dimethoxytriphenyl)methyl]-6'-(trifluoroacetamido)-3',5'-ethano-β-D-ribofuranosyl}thymine 3'-(2-cyanoethyl diisopropylphosphoramidite)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3'S,5'R,6'R)-1-{2'-deoxy-5'-O-[(4,4'-dimethoxytriphenyl)methyl]-6'-(trifluoroacetamido)-3',5'-ethano-β-D-ribofuranosyl}thymine 3'-(2-cyanoethyl diisopropylphosphoramidite)

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3'S,5'R,6'R)-1-{2'-deoxy-5'-O-[(4,4'-dimethoxytriphenyl)methyl]-6'-(trifluoroacetamido)-3',5'-ethano-β-D-ribofuranosyl}thymine 3'-(2-cyanoethyl diisopropylphosphoramidite)

There total 7 articles about (3'S,5'R,6'R)-1-{2'-deoxy-5'-O-[(4,4'-dimethoxytriphenyl)methyl]-6'-(trifluoroacetamido)-3',5'-ethano-β-D-ribofuranosyl}thymine 3'-(2-cyanoethyl diisopropylphosphoramidite) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 258505-09-8
(3'S,5'R,6'R)-1-{2'-deoxy-5'-O-[(4,4'-dimethoxytriphenyl)methyl]-6'-(trifluoroacetamido)-3',5'-ethano-β-D-ribofuranosyl}thymine

: 258505-11-2
(3'S,5'R,6'R)-1-{2'-deoxy-5'-O-[(4,4'-dimethoxytriphenyl)methyl]-6'-(trifluoroacetamido)-3',5'-ethano-β-D-ribofuranosyl}thymine 3'-(2-cyanoethyl diisopropylphosphoramidite)

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;
DOI:10.1002/(SICI)1522-2675(19991110)82:11<1813::AID-HLCA1813>3.0.CO;2-0

Reference yield:

: 239808-67-4
4,4’-dimethoxytrityl trifluoromethanesulfonate

: 258505-11-2
(3'S,5'R,6'R)-1-{2'-deoxy-5'-O-[(4,4'-dimethoxytriphenyl)methyl]-6'-(trifluoroacetamido)-3',5'-ethano-β-D-ribofuranosyl}thymine 3'-(2-cyanoethyl diisopropylphosphoramidite)

Guidance literature:: Multi-step reaction with 2 steps

1: 46 percent / 3A molecular sieves; pyridine / 9 h / 50 °C

2: 88 percent / iPr₂NEt / acetonitrile / 20 °C

With pyridine; 3 A molecular sieve; N-ethyl-N,N-diisopropylamine; In acetonitrile; 1: tritylation / 2: Condensation;
DOI:10.1002/(SICI)1522-2675(19991110)82:11<1813::AID-HLCA1813>3.0.CO;2-0

Reference yield:

: (2S,3aS,6R,6aR)-5-Amino-6-(tert-butyl-dimethyl-silanyloxy)-2-methoxy-hexahydro-cyclopenta[b]furan-3a-ol

: 258505-11-2
(3'S,5'R,6'R)-1-{2'-deoxy-5'-O-[(4,4'-dimethoxytriphenyl)methyl]-6'-(trifluoroacetamido)-3',5'-ethano-β-D-ribofuranosyl}thymine 3'-(2-cyanoethyl diisopropylphosphoramidite)

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / Et₃N / 1 h / 20 °C

2: 47 percent / N,O-bis(trimethylsilyl)acetamide; Me₃SiCl; Me₃SiOSO₂CF₃ / acetonitrile / 20 h / 3 °C

3: 95 percent / Bu₄NF*3H₂O; AcOH / acetonitrile / 2 h / 20 °C

4: 46 percent / 3A molecular sieves; pyridine / 9 h / 50 °C

5: 88 percent / iPr₂NEt / acetonitrile / 20 °C

With pyridine; chloro-trimethyl-silane; N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; 3 A molecular sieve; tetrabutyl ammonium fluoride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In acetonitrile; 1: Acylation / 2: Substitution / 3: deprotection / 4: tritylation / 5: Condensation;
DOI:10.1002/(SICI)1522-2675(19991110)82:11<1813::AID-HLCA1813>3.0.CO;2-0