N'-{9-[(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxymethyl)-3-methoxy-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-N,N-dimethyl-formamidine

Base Information

Chemical Name:N'-{9-[(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxymethyl)-3-methoxy-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-N,N-dimethyl-formamidine
CAS No.:183737-07-7
Molecular Formula:C₃₈H₄₁N₇O₇Si
Molecular Weight:735.872
Hs Code.:

N'-{9-[(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxymethyl)-3-methoxy-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-N,N-dimethyl-formamidine

Synonyms:N'-{9-[(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxymethyl)-3-methoxy-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-N,N-dimethyl-formamidine

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Chemical Property of N'-{9-[(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxymethyl)-3-methoxy-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-N,N-dimethyl-formamidine

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Technology Process of N'-{9-[(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxymethyl)-3-methoxy-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-N,N-dimethyl-formamidine

There total 3 articles about N'-{9-[(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxymethyl)-3-methoxy-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-N,N-dimethyl-formamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 183737-06-6
N'-{9-[(2R,3R,4R,5R)-5-(1,3-Dioxo-1,3-dihydro-isoindol-2-yloxymethyl)-4-hydroxy-3-methoxy-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-N,N-dimethyl-formamidine

: 183737-07-7
N'-{9-[(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxymethyl)-3-methoxy-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-N,N-dimethyl-formamidine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jo961549c

Reference yield:

: 524-38-9
N-hydroxyphthalimide

: 183737-07-7
N'-{9-[(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxymethyl)-3-methoxy-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-N,N-dimethyl-formamidine

Guidance literature:: Multi-step reaction with 2 steps

1: PPh₃ / tetrahydrofuran

2: imidazole / dimethylformamide / 18 h

With 1H-imidazole; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1080/07328319708006242

Reference yield:

: 183737-04-4
N₂-dimethylaminomethylene-2'-O-methylguanosine

: 183737-07-7
N'-{9-[(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxymethyl)-3-methoxy-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-N,N-dimethyl-formamidine

Guidance literature:: Multi-step reaction with 2 steps

1: PPh₃ / tetrahydrofuran

2: imidazole / dimethylformamide / 18 h

With 1H-imidazole; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1080/07328319708006242