183737-04-4 Usage
General Description
Guanosine, N-[(dimethylamino)methylene]-2'-O-methyl- is a modified form of the nucleoside guanosine, containing an additional N-[(dimethylamino)methylene] group at the 2'-O position. This chemical is commonly used in research and pharmaceutical applications for its ability to modulate RNA function and stability. It has been studied for its potential therapeutic effects on various diseases, including cancer and viral infections. The chemical modification of guanosine with the N-[(dimethylamino)methylene] group is believed to enhance its binding affinity and biological activity, making it a valuable tool for the development of RNA-targeted drugs and therapeutic interventions.
Check Digit Verification of cas no
The CAS Registry Mumber 183737-04-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,3,7,3 and 7 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 183737-04:
(8*1)+(7*8)+(6*3)+(5*7)+(4*3)+(3*7)+(2*0)+(1*4)=154
154 % 10 = 4
So 183737-04-4 is a valid CAS Registry Number.
183737-04-4Relevant articles and documents
Facile and efficient approach for the synthesis of N2-dimethylaminomethylene-2′-O-methylguanosine
Mukobata, Tsuyoshi,Ochi, Yosuke,Ito, Yuji,Wada, Shun-ichi,Urata, Hidehito
supporting information; experimental part, p. 129 - 131 (2010/04/05)
A convenient method for the synthesis of N2-dimethylaminomethylene-2′-O-methylguanosine (1), which is a useful intermediate for oligonucleotide construction, was developed. We chose the di-tert-butylsilyl group and the triisopropylbenzenesulfonyl group as sugar and base protecting groups, respectively. These protecting groups were stable during the 2′-O-methylation step with MeI and NaH. Our six-step synthesis of 1 is easy to perform using commercially available reagents, and requires only three chromatographic purifications. Compound 1 was obtained in 56% yield from guanosine.
