Carbamic acid, [(1R)-1-(aminomethyl)-2-methylpropyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, [(1R)-1-(aminomethyl)-2-methylpropyl]-, 1,1-dimethylethyl ester
• CAS No.: 400652-50-8
• Molecular Formula: C₁₀H₂₂N₂O₂
• Molecular Weight: 202.297
• Hs Code.: 2924190090
• Mol file: 400652-50-8.mol

Synonyms:Carbamic acid, [(1R)-1-(aminomethyl)-2-methylpropyl]-, 1,1-dimethylethyl ester

Chemical Property of Carbamic acid, [(1R)-1-(aminomethyl)-2-methylpropyl]-, 1,1-dimethylethyl ester

Chemical Property:

• Boiling Point: 292.4±23.0 °C(Predicted)
• PKA: 12.11±0.46(Predicted)
• Density: 0.961±0.06 g/cm3(Predicted)

Purity/Quality:

95%-98% ^*data from raw suppliers

N-Boc-[(R)-1-(aminomethyl)-2-methylpropyl]amine 97% ^*data from reagent suppliers

Safty Information:

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Technology Process of Carbamic acid, [(1R)-1-(aminomethyl)-2-methylpropyl]-, 1,1-dimethylethyl ester

There total 32 articles about Carbamic acid, [(1R)-1-(aminomethyl)-2-methylpropyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

[(1S)-1-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-2-methylpropyl]carbamic acid 1,1-dimethylethyl ester (864943-54-4) → (2S)-N2-(tert-butoxycarbonyl)-3-methyl-1,2-butanediamine (400652-49-5,400652-50-8)

Guidance literature:

With hydrazine; In methanol; at 20 ℃; for 22h; Heating / reflux;

Reference yield: 48.0%

tert-butyl[1-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-methylbutan-2-yl]carbamate (1529801-89-5) → 2-methyl-2-propanyl (1-amino-3-methyl-2-butanyl)carbamate (871235-24-4,400652-50-8)

Guidance literature:

With amino aminoalcohol; In ethanol; for 0.75h; Reflux;

Reference yield:

(R)-2-amino-3-methylbutanol (4276-09-9,473-75-6) → (2R)-N2-(tert-butoxycarbonyl)-3-methyl-1,2-butanediamine (400652-50-8)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 20 °C

2: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 20 °C

3: hydrazine hydrate / ethanol; dichloromethane / 20 °C

With hydrazine hydrate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In ethanol; dichloromethane; 2: Mitsunobu reaction;

DOI:10.1016/j.bmcl.2012.02.067

upstream raw materials:

(S)-tert-butyl 1-azido-3-methylbutan-2-ylcarbamate

nitromethane

[2-methyl-1-(toluene-4-sulfonyl)-propyl]-carbamic acid tert-butyl ester

(S)-2-<(tert-butoxycarbonyl)amino>-3-methylbutan-1-ol

Downstream raw materials:

rac-tert-butyl {1-[({6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-3-methylbutan-2-yl}carbamate

rac-tert-butyl {1-[({8-[(2,6-difluorobenzyl)oxy]-2,6-dimethylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-3-methylbutan-2-yl}carbamate

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