3-[3-(dimethylamino)prop-2-enoyl]-1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxypyridazin-4(1H)-one

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Chemical Name:3-[3-(dimethylamino)prop-2-enoyl]-1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxypyridazin-4(1H)-one
CAS No.:1357191-82-2
Molecular Formula:C₁₉H₁₈FN₅O₃
Molecular Weight:383.382
Hs Code.:

Synonyms:3-[3-(dimethylamino)prop-2-enoyl]-1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxypyridazin-4(1H)-one

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Chemical Property of 3-[3-(dimethylamino)prop-2-enoyl]-1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxypyridazin-4(1H)-one

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Technology Process of 3-[3-(dimethylamino)prop-2-enoyl]-1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxypyridazin-4(1H)-one

There total 2 articles about 3-[3-(dimethylamino)prop-2-enoyl]-1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxypyridazin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 3-(2-(2-fluoro-4-(1H-pyrazol-1-yl)phenyl)hydrazineylidene)-1-methoxypentane-2,4-dione

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1357191-82-2
3-[3-(dimethylamino)prop-2-enoyl]-1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxypyridazin-4(1H)-one

Guidance literature:: In N,N-dimethyl acetamide; at 57 - 67 ℃; for 3h; regioselective reaction; Inert atmosphere; Large scale;
DOI:10.1021/acs.oprd.8b00394

Reference yield:

: 1238704-28-3
3-acetyl-1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxypyridazin-4(1H)-one

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1357191-82-2
3-[3-(dimethylamino)prop-2-enoyl]-1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxypyridazin-4(1H)-one

Guidance literature:: In acetonitrile; at 80 ℃; for 12h; Concentration; Temperature; Time;

Reference yield: 91.0%

: 1357191-82-2
3-[3-(dimethylamino)prop-2-enoyl]-1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxypyridazin-4(1H)-one

: 100-63-0
phenylhydrazine

: 1238697-26-1
TAK-063

Guidance literature:: With acetic acid; at 20 - 30 ℃; for 4.6h; regioselective reaction; Inert atmosphere; Large scale;
DOI:10.1021/acs.oprd.8b00394