((S)-1-{(2R,5S)-5-[(R)-3-Benzenesulfonyl-1-(4-methoxy-benzyloxy)-propyl]-5-methyl-tetrahydro-furan-2-yl}-1,5-dimethyl-hex-4-enyloxy)-trimethyl-silane

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Chemical Name:((S)-1-{(2R,5S)-5-[(R)-3-Benzenesulfonyl-1-(4-methoxy-benzyloxy)-propyl]-5-methyl-tetrahydro-furan-2-yl}-1,5-dimethyl-hex-4-enyloxy)-trimethyl-silane
CAS No.:678999-06-9
Molecular Formula:C₃₃H₅₀O₆SSi
Molecular Weight:602.908
Hs Code.:

Synonyms:((S)-1-{(2R,5S)-5-[(R)-3-Benzenesulfonyl-1-(4-methoxy-benzyloxy)-propyl]-5-methyl-tetrahydro-furan-2-yl}-1,5-dimethyl-hex-4-enyloxy)-trimethyl-silane

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Chemical Property of ((S)-1-{(2R,5S)-5-[(R)-3-Benzenesulfonyl-1-(4-methoxy-benzyloxy)-propyl]-5-methyl-tetrahydro-furan-2-yl}-1,5-dimethyl-hex-4-enyloxy)-trimethyl-silane

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Technology Process of ((S)-1-{(2R,5S)-5-[(R)-3-Benzenesulfonyl-1-(4-methoxy-benzyloxy)-propyl]-5-methyl-tetrahydro-furan-2-yl}-1,5-dimethyl-hex-4-enyloxy)-trimethyl-silane

There total 14 articles about ((S)-1-{(2R,5S)-5-[(R)-3-Benzenesulfonyl-1-(4-methoxy-benzyloxy)-propyl]-5-methyl-tetrahydro-furan-2-yl}-1,5-dimethyl-hex-4-enyloxy)-trimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 75-77-4
chloro-trimethyl-silane

: 678999-18-3
(S)-2-{(2R,5S)-5-[(R)-3-Benzenesulfonyl-1-(4-methoxy-benzyloxy)-propyl]-5-methyl-tetrahydro-furan-2-yl}-6-methyl-hept-5-en-2-ol

: 678999-06-9
((S)-1-{(2R,5S)-5-[(R)-3-Benzenesulfonyl-1-(4-methoxy-benzyloxy)-propyl]-5-methyl-tetrahydro-furan-2-yl}-1,5-dimethyl-hex-4-enyloxy)-trimethyl-silane

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;
DOI:10.1021/ol036471i

Reference yield:

: 3112-85-4
methylphenylsulfonate

: 678999-06-9
((S)-1-{(2R,5S)-5-[(R)-3-Benzenesulfonyl-1-(4-methoxy-benzyloxy)-propyl]-5-methyl-tetrahydro-furan-2-yl}-1,5-dimethyl-hex-4-enyloxy)-trimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / n-BuLi; DMPU / tetrahydrofuran; hexane / 5 h / -78 - -25 °C

2: 78 percent / NaH / dimethylformamide / 3 h / 0 °C

3: 100 percent / imidazole / dimethylformamide / 0.17 h / 0 °C

With 1H-imidazole; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/ol036471i

Reference yield:

: 35189-96-9
3-methyl-2-butenylmagnesium chloride

: 678999-06-9
((S)-1-{(2R,5S)-5-[(R)-3-Benzenesulfonyl-1-(4-methoxy-benzyloxy)-propyl]-5-methyl-tetrahydro-furan-2-yl}-1,5-dimethyl-hex-4-enyloxy)-trimethyl-silane

Guidance literature:: Multi-step reaction with 7 steps

1: 70 percent / CuI / tetrahydrofuran / 0.5 h / -15 °C

2: 87 percent / aq. p-TsOH / ethanol / 2 h / 50 °C

3: 82 percent / pyridine / 1 h / 0 °C

4: 92 percent / K₂CO₃ / methanol / 0.33 h / 0 °C

5: 100 percent / n-BuLi; DMPU / tetrahydrofuran; hexane / 5 h / -78 - -25 °C

6: 78 percent / NaH / dimethylformamide / 3 h / 0 °C

7: 100 percent / imidazole / dimethylformamide / 0.17 h / 0 °C

With pyridine; 1H-imidazole; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; copper(l) iodide; n-butyllithium; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; ethanol; hexane; N,N-dimethyl-formamide;
DOI:10.1021/ol036471i