(E)-2-benzyl-4-(isobenzofuran-1(3H)-ylidene)-6,7-dimethoxy-3-(naphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline

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Chemical Name:(E)-2-benzyl-4-(isobenzofuran-1(3H)-ylidene)-6,7-dimethoxy-3-(naphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:1544263-30-0
Molecular Formula:C₃₆H₃₁NO₃
Molecular Weight:525.647
Hs Code.:

Synonyms:(E)-2-benzyl-4-(isobenzofuran-1(3H)-ylidene)-6,7-dimethoxy-3-(naphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of (E)-2-benzyl-4-(isobenzofuran-1(3H)-ylidene)-6,7-dimethoxy-3-(naphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline

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Technology Process of (E)-2-benzyl-4-(isobenzofuran-1(3H)-ylidene)-6,7-dimethoxy-3-(naphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline

There total 5 articles about (E)-2-benzyl-4-(isobenzofuran-1(3H)-ylidene)-6,7-dimethoxy-3-(naphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1544262-73-8
(2-(3-(N-(2-bromo-4,5-dimethoxybenzyl)-N-benzylamino)-3-(naphthalen-1-yl)prop-1-ynyl)phenyl)methanol

: 1544263-30-0
(E)-2-benzyl-4-(isobenzofuran-1(3H)-ylidene)-6,7-dimethoxy-3-(naphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 0.5h; stereoselective reaction; Inert atmosphere;
DOI:10.1039/c3ob42314j

Reference yield:

: 33577-99-0
2-ethynyl-benzoic acid methyl ester

: 1544263-30-0
(E)-2-benzyl-4-(isobenzofuran-1(3H)-ylidene)-6,7-dimethoxy-3-(naphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide / toluene / 3 h / 100 °C

2: lithium borohydride / tetrahydrofuran / 6 h / 20 °C

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 100 °C / Inert atmosphere

With copper(l) iodide; lithium borohydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1039/c3ob42314j

Reference yield:

: 1544263-16-2
methyl 2-(3-(benzyl(2-bromo-4,5-dimethoxybenzyl)amino)-3-(naphthalen-1-yl)prop-1-ynyl)benzoate

: 1544263-30-0
(E)-2-benzyl-4-(isobenzofuran-1(3H)-ylidene)-6,7-dimethoxy-3-(naphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: lithium borohydride / tetrahydrofuran / 6 h / 20 °C

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 100 °C / Inert atmosphere

With lithium borohydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/c3ob42314j