Technology Process of methyl 3-(4-methoxyphenyl)thiophene-2-carboxylate
There total 3 articles about methyl 3-(4-methoxyphenyl)thiophene-2-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-bromo-4-methoxy-benzene; 2-(1-methylimidazolyl) 2-thienyl ketone;
With
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; 2,6-dimethylbenzoic acid; potassium carbonate;
In
1-methyl-pyrrolidin-2-one;
at 150 ℃;
for 18h;
Schlenk technique;
Inert atmosphere;
With
methyl trifluoromethanesulfonate;
In
acetonitrile;
at 20 ℃;
for 2h;
Molecular sieve;
Inert atmosphere;
Schlenk technique;
methanol;
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
acetonitrile;
at 20 ℃;
for 1h;
Inert atmosphere;
Schlenk technique;
Molecular sieve;
DOI:10.1246/CL.200886
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 2 h / 0 - 20 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: tetrakis(triphenylphosphine) palladium(0); potassium phosphate / 1,4-dioxane / 4 h / 90 °C / Inert atmosphere
With
potassium phosphate; tetrakis(triphenylphosphine) palladium(0); tert.-butylnitrite; copper(ll) bromide;
In
1,4-dioxane; acetonitrile;
2.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.tetlet.2012.10.096
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine / acetonitrile / 0 - 20 °C
2.1: 2,6-dimethylbenzoic acid; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; potassium carbonate / 1-methyl-pyrrolidin-2-one / 18 h / 150 °C / Schlenk technique; Inert atmosphere
2.2: 2 h / 20 °C / Molecular sieve; Inert atmosphere; Schlenk technique
2.3: 1 h / 20 °C / Inert atmosphere; Schlenk technique; Molecular sieve
With
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; 2,6-dimethylbenzoic acid; potassium carbonate; triethylamine;
In
1-methyl-pyrrolidin-2-one; acetonitrile;
DOI:10.1246/CL.200886
