methyl 4-methoxy-9-(4-methoxybenzyl)-8,9-dihydro-7H-pyrimido[4,5-b]azepine-6-carboxylate

Base Information

Chemical Name:methyl 4-methoxy-9-(4-methoxybenzyl)-8,9-dihydro-7H-pyrimido[4,5-b]azepine-6-carboxylate
CAS No.:947665-27-2
Molecular Formula:C₁₉H₂₁N₃O₄
Molecular Weight:355.393
Hs Code.:

Synonyms:methyl 4-methoxy-9-(4-methoxybenzyl)-8,9-dihydro-7H-pyrimido[4,5-b]azepine-6-carboxylate

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Chemical Property of methyl 4-methoxy-9-(4-methoxybenzyl)-8,9-dihydro-7H-pyrimido[4,5-b]azepine-6-carboxylate

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Technology Process of methyl 4-methoxy-9-(4-methoxybenzyl)-8,9-dihydro-7H-pyrimido[4,5-b]azepine-6-carboxylate

There total 2 articles about methyl 4-methoxy-9-(4-methoxybenzyl)-8,9-dihydro-7H-pyrimido[4,5-b]azepine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 67-56-1
methanol

: 947661-83-8
methyl 4-((6-chloro-5-formylpyrimidin-4-yl)(4-methoxybenzyl)amino)butanoate

: 947665-27-2
methyl 4-methoxy-9-(4-methoxybenzyl)-8,9-dihydro-7H-pyrimido[4,5-b]azepine-6-carboxylate

Guidance literature:: With sodium methylate; carbonic acid dimethyl ester; In methanol; at 20 ℃; for 24h;
DOI:10.1016/j.bmc.2013.02.014

Reference yield:

: 5305-40-8
2,6-dichloro-pyrimidine carbaldehyde

: 947665-27-2
methyl 4-methoxy-9-(4-methoxybenzyl)-8,9-dihydro-7H-pyrimido[4,5-b]azepine-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate / acetonitrile / 15.5 h / 20 °C

2: sodium methylate; carbonic acid dimethyl ester / methanol / 24 h / 20 °C

With potassium phosphate; sodium methylate; carbonic acid dimethyl ester; In methanol; acetonitrile;
DOI:10.1016/j.bmc.2013.02.014

Reference yield:

: 947665-27-2
methyl 4-methoxy-9-(4-methoxybenzyl)-8,9-dihydro-7H-pyrimido[4,5-b]azepine-6-carboxylate

: methyl 4-((3-chloro-4-(3-(trifluoromethyl)phenoxy)phenyl)amino)-8,9-dihydro-7H-pyrimido[4,5-b]azepine-6-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / toluene / 20 h / 70 °C

2: trichlorophosphate / 96 h / 100 °C

3: pyridine hydrochloride / isopropyl alcohol / 14 h / 90 °C

With pyridine hydrochloride; trifluoroacetic acid; trichlorophosphate; In isopropyl alcohol; toluene;
DOI:10.1016/j.bmc.2013.02.014