(2E)-3-(4-{[2-nitro-5-(trifluoromethyl)phenoxy]methyl}phenyl)acrylic acid

Base Information

Chemical Name:(2E)-3-(4-{[2-nitro-5-(trifluoromethyl)phenoxy]methyl}phenyl)acrylic acid
CAS No.:913078-71-4
Molecular Formula:C₁₇H₁₂F₃NO₅
Molecular Weight:367.281
Hs Code.:

Synonyms:(2E)-3-(4-{[2-nitro-5-(trifluoromethyl)phenoxy]methyl}phenyl)acrylic acid

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Chemical Property of (2E)-3-(4-{[2-nitro-5-(trifluoromethyl)phenoxy]methyl}phenyl)acrylic acid

Chemical Property:

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Technology Process of (2E)-3-(4-{[2-nitro-5-(trifluoromethyl)phenoxy]methyl}phenyl)acrylic acid

There total 5 articles about (2E)-3-(4-{[2-nitro-5-(trifluoromethyl)phenoxy]methyl}phenyl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 913078-70-3
4-{[2-nitro-5-(trifluoromethyl)phenoxy]methyl}benzaldehyde

: 141-82-2
malonic acid

: 913078-71-4
(2E)-3-(4-{[2-nitro-5-(trifluoromethyl)phenoxy]methyl}phenyl)acrylic acid

Guidance literature:: With piperidine; pyridine; at 100 ℃; for 0.5h;
DOI:10.1016/j.bmc.2006.06.067

Reference yield:

: 907587-46-6
methyl 4-[(2-nitro-5-(trifluoromethyl)phenoxy)methyl]benzoate

: 913078-71-4
(2E)-3-(4-{[2-nitro-5-(trifluoromethyl)phenoxy]methyl}phenyl)acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / lithium borohydride / diethyl ether; methanol / Heating

2: 81 percent / dimethylsulfoxide; sulfur trioxide pyridine complex; diisopropylethylamine / ethyl acetate / 0.5 h

3: 90 percent / piperidine; pyridine / 0.5 h / 100 °C

With piperidine; pyridine; lithium borohydride; sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; ethyl acetate;
DOI:10.1016/j.bmc.2006.06.067

Reference yield:

: 913078-69-0
(4-{[2-nitro-5-(trifluoromethyl)phenoxy]methyl}phenyl)methanol

: 913078-71-4
(2E)-3-(4-{[2-nitro-5-(trifluoromethyl)phenoxy]methyl}phenyl)acrylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / dimethylsulfoxide; sulfur trioxide pyridine complex; diisopropylethylamine / ethyl acetate / 0.5 h

2: 90 percent / piperidine; pyridine / 0.5 h / 100 °C

With piperidine; pyridine; sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In ethyl acetate;
DOI:10.1016/j.bmc.2006.06.067