3-[2-(2,6-difluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid

Base Information

Chemical Name:3-[2-(2,6-difluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid
CAS No.:1282521-27-0
Molecular Formula:C₁₉H₂₀F₂O₄
Molecular Weight:350.362
Hs Code.:

Synonyms:3-[2-(2,6-difluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid

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Chemical Property of 3-[2-(2,6-difluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid

Chemical Property:

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Technology Process of 3-[2-(2,6-difluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid

There total 6 articles about 3-[2-(2,6-difluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1282521-26-9
3-[trans-2-(2,6-difluorophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid

: 1282521-27-0
3-[2-(2,6-difluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 24h;

Reference yield:

: 13036-02-7
Dimethyl 5-hydroxyisophthalate

: 1282521-27-0
3-[2-(2,6-difluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C

2.1: potassium hydroxide; methanol / 12 h / 100 °C

3.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C

3.2: 3 h / 0 °C

4.1: tribromide phosphate / tetrahydrofuran / 12 h / 0 - 20 °C

5.1: 3 h / 160 °C

6.1: potassium hydroxide / 18-crown-6 ether / dichloromethane / 16 h / 20 °C

7.1: hydrogen / palladium on activated charcoal / methanol / 24 h / 20 °C

With methanol; borane-THF; di-isopropyl azodicarboxylate; tribromide phosphate; hydrogen; triphenylphosphine; potassium hydroxide; 18-crown-6 ether; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1282520-89-1
5-(2-methoxy-(1S)-methyl-ethoxy)isophthalic acid dimethyl ester

: 1282521-27-0
3-[2-(2,6-difluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide; methanol / 12 h / 100 °C

2.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C

2.2: 3 h / 0 °C

3.1: tribromo phosphate / tetrahydrofuran / 12 h / 0 - 20 °C

4.1: 3 h / 160 °C

5.1: potassium hydroxide / 18-crown-6 ether / dichloromethane / 16 h / 20 °C

6.1: hydrogen / palladium on activated charcoal / methanol / 24 h / 20 °C

With methanol; borane-THF; tribromo phosphate; hydrogen; potassium hydroxide; 18-crown-6 ether; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;